Phenotypic transition of microglia into astrocyte-like cells associated with disease onset in a model of inherited ALS

Phenotypic transition of microglia into astrocyte-like cells associated with disease onset in a model of inherited ALS

Microglia and reactive astrocytes accumulate in the spinal cord of rats expressing the ALS-linked SOD1G93A mutation. We previously reported that the rapid progression of paralysis in ALS rats is associated with the appearance of proliferative astrocyte-like cells thatsurroundmotor neurons. These ce...

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Bibliographic Details
Main Authors: Emiliano eTrias, Pablo eDíaz-Amarilla, Silvia eOlivera-Bravo, Eugenia eIsasi, Derek A Drechsel, Nathan eLopez, Charles Samuel Bradford, Kyle Edward Ireton, Joseph S Beckman, Luis Hector Barbeito
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-12-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Astrocytes
Microglia
Neuroinflammation
ALS
AbA cells
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00274/full

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