Direct conversion of human fibroblasts into dopaminergic neuron-like cells using small molecules and protein factors

Direct conversion of human fibroblasts into dopaminergic neuron-like cells using small molecules and protein factors

Abstract Background Generation of neurons is essential in cell replacement therapy for neurodegenerative disorders like Parkinson’s disease. Several studies have reported the generation of dopaminergic (DA) neurons from mouse and human fibroblasts by ectopic expression of transcription factors, in w...

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Bibliographic Details
Main Authors: Hua Qin, An-Dong Zhao, Meng-Li Sun, Kui Ma, Xiao-Bing Fu
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Military Medical Research
Subjects:
Human fibroblasts
Dopaminergic neurons
Parkinson’s disease
Small molecules
Reprogramming
Transdifferentiation
Online Access:http://link.springer.com/article/10.1186/s40779-020-00284-2

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