Protective Effect of Unacylated Ghrelin on Compression-Induced Skeletal Muscle Injury Mediated by SIRT1-Signaling

Protective Effect of Unacylated Ghrelin on Compression-Induced Skeletal Muscle Injury Mediated by SIRT1-Signaling

Unacylated ghrelin, the predominant form of circulating ghrelin, protects myotubes from cell death, which is a known attribute of pressure ulcers. In this study, we investigated whether unacylated ghrelin protects skeletal muscle from pressure-induced deep tissue injury by abolishing necroptosis and...

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Bibliographic Details
Main Authors: Felix N. Ugwu, Angus P. Yu, Thomas K. Sin, Bjorn T. Tam, Christopher W. Lai, S. C. Wong, Parco M. Siu
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Physiology
Subjects:
pressure sores
unacylated ghrelin
EX527
apoptosis
necroptosis
oxidative stress
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.00962/full

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