Effect of D-penicillamine in prevention of post operative pelvic adhesion formation in rat
INTRODUCTION: Adhesion formation after pelvic surgery is still a major cause of several morbidities such as infertility, pain, bowel obstruction and subsequent intra-operative complications. Our aim was to investigate the effects of d-penicillamine in preventing adhesion formation in rat uterine hor...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2006-12-01
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| Series: | Journal of Research in Medical Sciences |
| Subjects: | |
| Online Access: | http://journals.mui.ac.ir/jrms/article/view/205 |
| Summary: | INTRODUCTION: Adhesion formation after pelvic surgery is still a major cause of several morbidities such as infertility, pain, bowel obstruction and subsequent intra-operative complications. Our aim was to investigate the effects of d-penicillamine in preventing adhesion formation in rat uterine horn. METHODS: This experimental trial was conducted on 30 rats. The rats were randomly assigned to two groups of 15. Measurable serosal injury was created using a standard technique. The rats in one of the two groups were given 17 mg/kg of d-penicillamine. All of the animals were operated on 4 weeks after surgery and adhesions were assessed and scored by an examiner who was blind to the test. RESULTS: Frequency of severe adhesions in control and case groups were 76 and zero percent, respectively. Total scores of adhesions were found to be significantly reduced in the d-penicillamine treatment group when compared with control group (P = 0). CONCLUSION: This study showed that penicillamine can decrease the chance of post-operative intra-peritoneal adhesion formation. KEY WORDS: Adhesion formation, d-penicillamine, pelvis. |
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| ISSN: | 1735-1995 1735-7136 |