Nonsmall cell lung carcinoma: diagnostic difficulties in small biopsies and cytological specimens

Nonsmall cell lung carcinoma: diagnostic difficulties in small biopsies and cytological specimens

The pathological and molecular classification of lung cancer has become substantially more complex over the past decade. For diagnostic purposes on small samples, additional stains are frequently required to distinguish between squamous cell carcinoma and adenocarcinoma. Subsequently, for advanced n...

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Main Authors: Lukas Bubendorf, Sylvie Lantuejoul, Adrianus J. de Langen, Erik Thunnissen
Format: Article
Language:English
Published: European Respiratory Society 2017-06-01
Series:European Respiratory Review
Online Access:http://err.ersjournals.com/content/26/144/170007.full
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spelling doaj-fc0ab9dcaaeb4a72a703e0828e0b97742020-11-24T21:45:55ZengEuropean Respiratory SocietyEuropean Respiratory Review0905-91801600-06172017-06-012614410.1183/16000617.0007-20170007-2017Nonsmall cell lung carcinoma: diagnostic difficulties in small biopsies and cytological specimensLukas Bubendorf0Sylvie Lantuejoul1Adrianus J. de Langen2Erik Thunnissen3 Institut für Pathologie, Universität Basel, Basel, Switzerland Dept of Biopathology, Centre Léon Bérard UNICANCER, Lyon, France Dept of Respiratory Diseases, VU University Medical Center, Amsterdam, The Netherlands Dept of Pathology, VU University Medical Center, Amsterdam, The Netherlands The pathological and molecular classification of lung cancer has become substantially more complex over the past decade. For diagnostic purposes on small samples, additional stains are frequently required to distinguish between squamous cell carcinoma and adenocarcinoma. Subsequently, for advanced nonsquamous cell nonsmall cell lung carcinoma (NSCLC) patients, predictive analyses on epidermal growth factor receptor, anaplastic lymphoma kinase and ROS1 are required. In NSCLCs negative for these biomarkers, programmed death ligand-1 immunohistochemistry is performed. Small samples (biopsy and cytology) require “tissue” management, which is best achieved by the interaction of all physicians involved.http://err.ersjournals.com/content/26/144/170007.full
collection DOAJ
language English
format Article
sources DOAJ
author Lukas Bubendorf
Sylvie Lantuejoul
Adrianus J. de Langen
Erik Thunnissen
spellingShingle Lukas Bubendorf
Sylvie Lantuejoul
Adrianus J. de Langen
Erik Thunnissen
Nonsmall cell lung carcinoma: diagnostic difficulties in small biopsies and cytological specimens
European Respiratory Review
author_facet Lukas Bubendorf
Sylvie Lantuejoul
Adrianus J. de Langen
Erik Thunnissen
author_sort Lukas Bubendorf
title Nonsmall cell lung carcinoma: diagnostic difficulties in small biopsies and cytological specimens
title_short Nonsmall cell lung carcinoma: diagnostic difficulties in small biopsies and cytological specimens
title_full Nonsmall cell lung carcinoma: diagnostic difficulties in small biopsies and cytological specimens
title_fullStr Nonsmall cell lung carcinoma: diagnostic difficulties in small biopsies and cytological specimens
title_full_unstemmed Nonsmall cell lung carcinoma: diagnostic difficulties in small biopsies and cytological specimens
title_sort nonsmall cell lung carcinoma: diagnostic difficulties in small biopsies and cytological specimens
publisher European Respiratory Society
series European Respiratory Review
issn 0905-9180
1600-0617
publishDate 2017-06-01
description The pathological and molecular classification of lung cancer has become substantially more complex over the past decade. For diagnostic purposes on small samples, additional stains are frequently required to distinguish between squamous cell carcinoma and adenocarcinoma. Subsequently, for advanced nonsquamous cell nonsmall cell lung carcinoma (NSCLC) patients, predictive analyses on epidermal growth factor receptor, anaplastic lymphoma kinase and ROS1 are required. In NSCLCs negative for these biomarkers, programmed death ligand-1 immunohistochemistry is performed. Small samples (biopsy and cytology) require “tissue” management, which is best achieved by the interaction of all physicians involved.
url http://err.ersjournals.com/content/26/144/170007.full
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AT sylvielantuejoul nonsmallcelllungcarcinomadiagnosticdifficultiesinsmallbiopsiesandcytologicalspecimens
AT adrianusjdelangen nonsmallcelllungcarcinomadiagnosticdifficultiesinsmallbiopsiesandcytologicalspecimens
AT erikthunnissen nonsmallcelllungcarcinomadiagnosticdifficultiesinsmallbiopsiesandcytologicalspecimens
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