Switch in KRAS mutational status during an unusual course of disease in a patient with advanced pancreatic adenocarcinoma: implications for translational research

Switch in KRAS mutational status during an unusual course of disease in a patient with advanced pancreatic adenocarcinoma: implications for translational research

Abstract Background Despite the introduction of novel effective treatment regimens like gemcitabine plus nab-paclitaxel and FOLFIRINOX, pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive epithelial tumors. Among the genetic alterations frequently found in PDAC, mutations in t...

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Bibliographic Details
Main Authors: Sibylle Baechmann, Steffen Ormanns, Michael Haas, Stephan Kruger, Anna Remold, Dominik Paul Modest, Thomas Kirchner, Andreas Jung, Jens Werner, Volker Heinemann, Stefan Boeck
Format: Article
Language:English
Published: BMC 2017-05-01
Series:BMC Cancer
Subjects:
Pancreatic ductal adenocarcinoma (PDAC)
KRAS mutation
Tumor heterogeneity
Online Access:http://link.springer.com/article/10.1186/s12885-017-3376-4

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