Low-Grade Systemic Inflammation Profile, Unrelated to Homocysteinemia, in Obese Children
To investigate in prepubertal obese children (POC) the profile of chronic low-grade systemic inflammation (CLGSI) and its relation to homocysteinemia, 72 POC were evaluated for serum C-reactive protein (CRP) and amyloid A (SAA) levels, both markers of CLGSI, and plasma levels of total homocysteine (...
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Hindawi Limited
2005-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/MI.2005.337 |
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doaj-fbe7e7da91e3450a81f46b77c7b0e0ce2020-11-24T22:57:48ZengHindawi LimitedMediators of Inflammation0962-93511466-18612005-01-012005633734210.1155/MI.2005.337Low-Grade Systemic Inflammation Profile, Unrelated to Homocysteinemia, in Obese ChildrenEmanuel V. Economou0Ariadne V. Malamitsi-Puchner1Christos P. Pitsavos2Evangelia E. Kouskouni3Ioanna Magaziotou-Elefsinioti4George Creatsas5Hormone Laboratory, 2nd Clinic for Obstetrics and Gynecology, Aretaieion Hospital, University of Athens, Athens 11528, GreeceDivision of Neonatology, 2nd Clinic for Obstetrics and Gynecology, Aretaieion Hospital, University of Athens, Athens 11528, GreeceDepartment of Cardiology, Hippokration Hospital, University of Athens, Athens 11527, GreeceHormone Laboratory, 2nd Clinic for Obstetrics and Gynecology, Aretaieion Hospital, University of Athens, Athens 11528, GreeceDepartment of Pediatrics, Tzaneion Hospital, Pireaus 18536, Greece2nd Clinic for Obstetrics and Gynecology, Aretaieion Hospital, University of Athens, Athens 11528, GreeceTo investigate in prepubertal obese children (POC) the profile of chronic low-grade systemic inflammation (CLGSI) and its relation to homocysteinemia, 72 POC were evaluated for serum C-reactive protein (CRP) and amyloid A (SAA) levels, both markers of CLGSI, and plasma levels of total homocysteine (tHcy), an independent risk factor for adult atherosclerosis, in comparison to 42 prepubertal lean children (PLC). The main observations in POC were higher CRP levels compared to PLC, positive association of SAA levels to CRP levels, no association of CRP or SAA levels to tHcy levels. Thus, in POC, positively interrelated to each other, elevated CRP and unaltered SAA levels reveal a unique profile of the CLGSI, not explaining homocysteinemia-induced risk for future atherosclerosis.http://dx.doi.org/10.1155/MI.2005.337 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Emanuel V. Economou Ariadne V. Malamitsi-Puchner Christos P. Pitsavos Evangelia E. Kouskouni Ioanna Magaziotou-Elefsinioti George Creatsas |
| spellingShingle |
Emanuel V. Economou Ariadne V. Malamitsi-Puchner Christos P. Pitsavos Evangelia E. Kouskouni Ioanna Magaziotou-Elefsinioti George Creatsas Low-Grade Systemic Inflammation Profile, Unrelated to Homocysteinemia, in Obese Children Mediators of Inflammation |
| author_facet |
Emanuel V. Economou Ariadne V. Malamitsi-Puchner Christos P. Pitsavos Evangelia E. Kouskouni Ioanna Magaziotou-Elefsinioti George Creatsas |
| author_sort |
Emanuel V. Economou |
| title |
Low-Grade Systemic Inflammation Profile, Unrelated to
Homocysteinemia, in Obese Children |
| title_short |
Low-Grade Systemic Inflammation Profile, Unrelated to
Homocysteinemia, in Obese Children |
| title_full |
Low-Grade Systemic Inflammation Profile, Unrelated to
Homocysteinemia, in Obese Children |
| title_fullStr |
Low-Grade Systemic Inflammation Profile, Unrelated to
Homocysteinemia, in Obese Children |
| title_full_unstemmed |
Low-Grade Systemic Inflammation Profile, Unrelated to
Homocysteinemia, in Obese Children |
| title_sort |
low-grade systemic inflammation profile, unrelated to
homocysteinemia, in obese children |
| publisher |
Hindawi Limited |
| series |
Mediators of Inflammation |
| issn |
0962-9351 1466-1861 |
| publishDate |
2005-01-01 |
| description |
To investigate in prepubertal obese children (POC) the
profile of chronic low-grade systemic inflammation (CLGSI) and
its relation to homocysteinemia, 72 POC were evaluated for serum
C-reactive protein (CRP) and amyloid A (SAA) levels, both markers
of CLGSI, and plasma levels of total homocysteine (tHcy), an
independent risk factor for adult atherosclerosis, in comparison
to 42 prepubertal lean children (PLC). The main observations in
POC were higher CRP levels compared to PLC, positive association
of SAA levels to CRP levels, no association of CRP or SAA levels
to tHcy levels. Thus, in POC, positively interrelated to each
other, elevated CRP and unaltered SAA levels reveal a unique
profile of the CLGSI, not explaining homocysteinemia-induced risk
for future atherosclerosis. |
| url |
http://dx.doi.org/10.1155/MI.2005.337 |
| work_keys_str_mv |
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