SIRNA-directed in vivo silencing of androgen receptor inhibits the growth of castration-resistant prostate carcinomas.

SIRNA-directed in vivo silencing of androgen receptor inhibits the growth of castration-resistant prostate carcinomas.

BACKGROUND: Prostate carcinomas are initially dependent on androgens, and castration or androgen antagonists inhibit their growth. After some time though, tumors become resistant and recur with a poor prognosis. The majority of resistant tumors still expresses a functional androgen receptor (AR), fr...

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Bibliographic Details
Main Authors: Daniel Compagno, Carole Merle, Aurélie Morin, Cristèle Gilbert, Jacques R R Mathieu, Aline Bozec, Claire Mauduit, Mohammed Benahmed, Florence Cabon
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC1994591?pdf=render

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