Pathogen-associated molecular patterns alter molecular clock gene expression in mouse splenocytes.

Pathogen-associated molecular patterns alter molecular clock gene expression in mouse splenocytes.

Circadian rhythms are endogenous 24-h oscillations that influence a multitude of physiological processes. The pathogen-associated molecular pattern (PAMP), lipopolysaccharide, has been shown to modify the circadian molecular clock. The aim of this study was to determine if other PAMPs alter clock ge...

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Main Author: Adam C Silver
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5734770?pdf=render
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spelling doaj-fbce8b7557b34f90939883b319ee9aa82020-11-25T01:22:06ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-011212e018994910.1371/journal.pone.0189949Pathogen-associated molecular patterns alter molecular clock gene expression in mouse splenocytes.Adam C SilverCircadian rhythms are endogenous 24-h oscillations that influence a multitude of physiological processes. The pathogen-associated molecular pattern (PAMP), lipopolysaccharide, has been shown to modify the circadian molecular clock. The aim of this study was to determine if other PAMPs alter clock gene expression. Therefore, mRNA levels of clock genes (Per2, Bmal1, Rev-erbα, and Dbp) were measured after an ex vivo challenge with several PAMPs and to further test the relevance of PAMP alteration of the molecular clock, an in vivo poly(I:C) challenge was performed. This study revealed that several other PAMPs are also capable of altering clock gene expression.http://europepmc.org/articles/PMC5734770?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Adam C Silver
spellingShingle Adam C Silver
Pathogen-associated molecular patterns alter molecular clock gene expression in mouse splenocytes.
PLoS ONE
author_facet Adam C Silver
author_sort Adam C Silver
title Pathogen-associated molecular patterns alter molecular clock gene expression in mouse splenocytes.
title_short Pathogen-associated molecular patterns alter molecular clock gene expression in mouse splenocytes.
title_full Pathogen-associated molecular patterns alter molecular clock gene expression in mouse splenocytes.
title_fullStr Pathogen-associated molecular patterns alter molecular clock gene expression in mouse splenocytes.
title_full_unstemmed Pathogen-associated molecular patterns alter molecular clock gene expression in mouse splenocytes.
title_sort pathogen-associated molecular patterns alter molecular clock gene expression in mouse splenocytes.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2017-01-01
description Circadian rhythms are endogenous 24-h oscillations that influence a multitude of physiological processes. The pathogen-associated molecular pattern (PAMP), lipopolysaccharide, has been shown to modify the circadian molecular clock. The aim of this study was to determine if other PAMPs alter clock gene expression. Therefore, mRNA levels of clock genes (Per2, Bmal1, Rev-erbα, and Dbp) were measured after an ex vivo challenge with several PAMPs and to further test the relevance of PAMP alteration of the molecular clock, an in vivo poly(I:C) challenge was performed. This study revealed that several other PAMPs are also capable of altering clock gene expression.
url http://europepmc.org/articles/PMC5734770?pdf=render
work_keys_str_mv AT adamcsilver pathogenassociatedmolecularpatternsaltermolecularclockgeneexpressioninmousesplenocytes
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