Cloning and characterization of an adenoviral vector for highly efficient and doxycycline – suppressible expression of bioactive human single – chain interleukin 12 in colon cancer

Cloning and characterization of an adenoviral vector for highly efficient and doxycycline – suppressible expression of bioactive human single – chain interleukin 12 in colon cancer

<p>Abstract</p> <p>Background</p> <p>Interleukin-12 (IL-12) is well characterized to induce cellular antitumoral immunity by activation of NK-cells and T-lymphocytes. However, systemic administration of recombinant human IL-12 resulted in severe toxicity without percept...

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Bibliographic Details
Main Authors: Schäfer Hansjörg, Thaiss Friedrich, Stahmer Ingrid, Krüger Karen, Krieger Thorsten, Wulff Holger, Block Andreas
Format: Article
Language:English
Published: BMC 2007-06-01
Series:BMC Biotechnology
Online Access:http://www.biomedcentral.com/1472-6750/7/35

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