Extracellular Interactions of Alpha-Synuclein in Multiple System Atrophy

Extracellular Interactions of Alpha-Synuclein in Multiple System Atrophy

Multiple system atrophy, characterized by atypical Parkinsonism, results from central nervous system (CNS) cell loss and dysfunction linked to aggregates of the normally pre-synaptic α-synuclein protein. Mostly cytoplasmic pathological α-synuclein inclusion bodies occur predominant...

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Bibliographic Details
Main Authors: Dario Valdinocci, Rowan A. W. Radford, Michael Goulding, Junna Hayashi, Roger S. Chung, Dean L. Pountney
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:International Journal of Molecular Sciences
Subjects:
α-synuclein
multiple system atrophy
gliosis
glymphatic
neuroinflammation
chaperone
Online Access:https://www.mdpi.com/1422-0067/19/12/4129

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https://www.mdpi.com/1422-0067/19/12/4129

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