Atezolizumab-induced bilateral anterior uveitis: A case report

• Main Authors: Tsuyoshi Mito, Shun Takeda, Nozomu Motono, Hiroshi Sasaki
• Format: Article
• Language: English
• Published: Elsevier 2021-12-01
• Series: American Journal of Ophthalmology Case Reports
• Subjects: Atezolizumab; PD-L1 inhibitor; Anterior uveitis; Immune-related adverse events (irAEs)
• Online Access: http://www.sciencedirect.com/science/article/pii/S2451993621002140

Purpose: To report a case of bilateral anterior uveitis undergoing atezolizumab treatment for advanced non-small cell lung cancer (NSCLC). Observations: A 64-year-old man was receiving atezolizumab for metastatic programmed cell death ligand 1 (PD-L1) positive NSCLC as first line therapy. Three weeks after first atezolizumab administration, he complained of blurry vision in both eyes and was referred to our clinic. At initial presentation, slit lamp examination revealed bilateral Descemet membrane folds, fine keratic precipitates, and anterior chamber cells 2+. Dilated fundus examination showed no abnormal findings. A complete laboratory evaluation ruled out infectious or autoimmune causes of the uveitis and he was diagnosed with uveitis caused by atezolizumab. Atezolizumab was suspended, administration of topical corticosteroid was initiated, and the anterior uveitis was resolved within one month. Conclusion and importance: This is the first case report of bilateral anterior uveitis associated with atezolizumab and that PD-1 and PD-L1 inhibitors cause uveitis.