Metastasis of Uveal Melanoma with Monosomy-3 Is Associated with a Less Glycogenetic Gene Expression Profile and the Dysregulation of Glycogen Storage

Metastasis of Uveal Melanoma with Monosomy-3 Is Associated with a Less Glycogenetic Gene Expression Profile and the Dysregulation of Glycogen Storage

The prolonged storage of glucose as glycogen can promote the quiescence of tumor cells, whereas the accumulation of an aberrant form of glycogen without the primer protein glycogenin can induce the metabolic switch towards a glycolytic phenotype. Here, we analyzed the expression of <i>n</i&...

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Bibliographic Details
Main Authors: Siranush Vardanyan, Anton Brosig, Hartmut Merz, Mahdy Ranjbar, Vinodh Kakkassery, Salvatore Grisanti, Aysegül Tura
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cancers
Subjects:
uveal melanoma
monosomy-3
glycogen
glycogenin
insulin resistance
tumor dormancy
Online Access:https://www.mdpi.com/2072-6694/12/8/2101

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