Mechanism of KLF4 Protection against Acute Liver Injury via Inhibition of Apelin Signaling

Mechanism of KLF4 Protection against Acute Liver Injury via Inhibition of Apelin Signaling

Krüppel-like factor 4 (KLF4) is a key transcription factor that regulates genes involved in the proliferation or differentiation in different tissues. Apelin plays roles in cardiovascular functions, metabolic disease, and homeostatic disorder. However, the biological function of apelin in liver dise...

Full description

Bibliographic Details
Main Authors:	Weitao Ji, Hongyun Shi, Hailin Shen, Jing Kong, Jiayi Song, Hongyan Bian, Xinrui Lv
Format:	Article
Language:	English
Published:	Hindawi Limited 2019-01-01
Series:	Oxidative Medicine and Cellular Longevity
Online Access:	http://dx.doi.org/10.1155/2019/6140360

Similar Items

The Role of the Apelin/APJ System in the Regulation of Liver Disease
by: Wei-Dong Chen, et al.
Published: (2017-04-01)

Apelin-13 Administration Protects Against LPS-Induced Acute Lung Injury by Inhibiting NF-κB Pathway and NLRP3 Inflammasome Activation
by: Hailin Zhang, et al.
Published: (2018-09-01)

Relationship between Apelin/APJ Signaling, Oxidative Stress, and Diseases
by: Shuangyu Lv, et al.
Published: (2021-01-01)

Inhibition of KLF6 and liver fibrosis by small molecule compounds
by: Min-Che Huang, et al.
Published: (2015)

KLF11 protects against abdominal aortic aneurysm through inhibition of endothelial cell dysfunction
by: Guizhen Zhao, et al.
Published: (2021-03-01)

Apelin-13 inhibits apoptosis and excessive autophagy in cerebral ischemia/reperfusion injury
by: Zi-Qi Shao, et al.
Published: (2021-01-01)

RORα Induces KLF4-Mediated M2 Polarization in the Liver Macrophages that Protect against Nonalcoholic Steatohepatitis
by: Yong-Hyun Han, et al.
Published: (2017-07-01)

Endogenous Apelin Is Protective Against Age-Associated Loss of Retinal Ganglion Cells in Mice
by: Yuki Ishimaru, et al.
Published: (2020-03-01)

Apelin: A new biomarker in fatty liver disease
by: Semih Kalyon, et al.
Published: (2021-09-01)

Lateral intracerebroventricular injection of Apelin-13 inhibits apoptosis after cerebral ischemia/reperfusion injury
by: Xiao-ge Yan, et al.
Published: (2015-01-01)

microRNA-182 Negatively Influences the Neuroprotective Effect of Apelin Against Neuronal Injury in Epilepsy
by: Dong H, et al.
Published: (2020-01-01)

Klf6 protects β-cells against insulin resistance-induced dedifferentiation
by: Christopher Dumayne, et al.
Published: (2020-05-01)

The Effects of Apelin and Elabela Ligands on Apelin Receptor Distinct Signaling Profiles
by: Yunlu Jiang, et al.
Published: (2021-03-01)

Is serum apelin related to portal hemodynamics in patients with liver cirrhosis?
by: Ashraf G Dala, et al.
Published: (2018-01-01)

Roles of the Hepatic Endocannabinoid and Apelin Systems in the Pathogenesis of Liver Fibrosis
by: Pedro Melgar-Lesmes, et al.
Published: (2019-10-01)

APELIN-12 AND APELIN-36 IN SPUTUM OF PATIENTS WITH BRONCHIAL ASTHMA
by: V. N. Mineev, et al.
Published: (2017-06-01)

Inhibition of the mitochondrial complex-1 protects against carbon tetrachloride-induced acute liver injury
by: Hu Hua, et al.
Published: (2019-07-01)

A Potential Role of Apelin-13 against Hepatic Injury and Metabolic Disorders in Preeclampsia Induced by L-NAME
by: Reham Z. Hamza, et al.
Published: (2021-03-01)

The Apelin/APJ System in Psychosis and Neuropathy
by: Shuang-Yu Lv, et al.
Published: (2020-03-01)

Inhibition of the HEG1–KRIT1 interaction increases KLF4 and KLF2 expression in endothelial cells
by: Miguel Alejandro Lopez‐Ramirez, et al.
Published: (2021-05-01)

Apelin and energy metabolism
by: Chantal eBertrand, et al.
Published: (2015-04-01)

Modulators of the apelin receptor
by: Fitzpatrick, Christopher Mark
Published: (2018)

Apelin inhibition prevents resistance and metastasis associated with anti‐angiogenic therapy
by: Iris Uribesalgo, et al.
Published: (2019-08-01)

Protective Effects of Antrodia Cinnamomea Against Liver Injury
by: Yen-Wenn Liu, et al.
Published: (2012-10-01)

Hordenine Protects Against Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting Inflammation
by: Xiyue Zhang, et al.
Published: (2021-09-01)

The zinc finger transcription factor, KLF2, protects against COVID-19 associated endothelial dysfunction
by: Suowen Xu, et al.
Published: (2021-07-01)

Evaluation of Apelin and Apelin Receptor Level in the Primary Tumor and Serum of Colorectal Cancer Patients
by: Marta Podgórska, et al.
Published: (2019-09-01)

Apelin-13 as a novel target for intervention in secondary injury after traumatic brain injury
by: Hai-jun Bao, et al.
Published: (2016-01-01)

Protective Effects of Nutria Bile against Thioacetamide-Induced Liver Injury in Mice
by: Joo-Yeon Kong, et al.
Published: (2019-01-01)

Melatonin prevents lung injury by regulating apelin 13 to improve mitochondrial dysfunction
by: Lu Zhang, et al.
Published: (2019-07-01)

Interleukin-24 protects against liver injury in mouse models
by: Hsiao-Hsuan Wang, et al.
Published: (2021-02-01)

Biliverdin protects against liver ischemia reperfusion injury in swine.
by: Barbara Andria, et al.
Published: (2013-01-01)

Melatonin Protective Effects against Liver Ischemia/Reperfusion Injury
by: Abbas Khonakdar-Tarsi, et al.
Published: (2016-02-01)

Chlorogenic acid protects against cholestatic liver injury in rats
by: Duohu Wu, et al.
Published: (2015-11-01)

Apelin and its Receptor: An Overview
by: Rajeev Gandham, et al.
Published: (2019-06-01)

Effects of Apelin on Cardiovascular Aging
by: Ying Zhou, et al.
Published: (2017-12-01)

Studies on the apelin/APJ system
by: Macaluso, Nicholas-Jacomo Maximilian
Published: (2011)

Apelin : a cardioprotective adipocytokine
by: Simpkin, J. C.
Published: (2007)

The Role of Apelin/Apelin Receptor in Energy Metabolism and Water Homeostasis: A Comprehensive Narrative Review
by: Gonghui Hu, et al.
Published: (2021-02-01)

The Partial Role of KLF4 and KLF5 in Gastrointestinal Tumors
by: Jun-Chen Li, et al.
Published: (2021-01-01)