EFFECT OF 3-YEARS ADHERENCE TO A LOW PROTEIN DIET ON THE PROGRESSION OF GLOMERULAR FILTRATION RATE IN CHRONIC KIDNEY DISEASE PATIENTS

• Main Authors: Felipe Rizzetto, Julianne S Cota, Karina SG Luna, Vanessa LM de Oliveira, Luis Guillermo C Velarde, Denise Mafra
• Format: Article
• Language: English
• Published: The Korean Society of Nephrology 2012-06-01
• Series: Kidney Research and Clinical Practice
• Online Access: http://www.sciencedirect.com/science/article/pii/S2211913212005062

Low protein diet for patients with chronic kidney disease (CKD) during conservative treatment (CT) aims to reduce the progression and symptoms of the CKD. This study aimed to evaluate the glomerular filtration rate (GFR) in patients receiving low protein diet during 3 years (≅ 4 clinic visits per year). The study comprised 321 patients with CKD on CT from a Renal Nutrition Ambulatory of a Federal Lagoa Hospital. All patients received dietary prescription according to NKF-K/DOQI recommendations and the diet adherence was evaluated with patients being asked whether they were adhering to the treatment and through reported dietary intake (2 weekdays and 1 weekend day). Patients were divided in 4 groups: diabetes Mellitus (DM) patients who adhered (G1) and not adhered to the diet (G2), and patients without DM who adhered (G3) and not adhered to the diet (G4). Groups Before After Group 1-DM (n=83) Cr (mg/dL) 1.9 ± 0.6 1.6 ± 0.7* GFR (mL/min) 37.8 ± 14.4 46.6 ± 17.3** Group 2-DM (n=106) Cr (mg/dL) 1.9 ± 0.7 2.03 ± 0.7 GFR (mL/min) 43.8 ± 17.3 42.6 ± 13.3 Group 3-non-DM (n=75) Cr (mg/dL) 2.2 ± 0.8 1.8± 0.8* GFR (mL/min) 34.3 ± 13.1 40.9 ± 21.7 Group 4-non-DM (n=57) Cr (mg/dL) 2.2 ± 0.8 2.4 ± 1.0 GFR (mL/min) 39.9 ± 19.0 35.2 ± 18.4 There was no difference between diabetic and non-diabetic patients who adhered to the diet. Both groups showed improvement on GFR. In conclusion, these analyses suggest that a lower protein intake retards the progression of renal disease.