Safety and tolerability of liquid amikacin in antibiotic-loaded bone cement – a case series
<p>High-dose liquid antibiotics are uncommon in bone cement. We present a case series of patients in which up to 16 mL of liquid amikacin (250 mg mL<span class="inline-formula"><sup>−1</sup></span>) was successfully incorporated into bone cement to treat perip...
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Copernicus Publications
2021-04-01
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Series: | Journal of Bone and Joint Infection |
Online Access: | https://jbji.copernicus.org/articles/6/147/2021/jbji-6-147-2021.pdf |
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doaj-fb9189e986d141e9ab93c4d78c3b1c022021-04-26T06:32:28ZengCopernicus PublicationsJournal of Bone and Joint Infection2206-35522021-04-01614715010.5194/jbji-6-147-2021Safety and tolerability of liquid amikacin in antibiotic-loaded bone cement – a case seriesD. B. G. Tai0N. J. Brinkman1O. Abu Saleh2D. R. Osmon3M. P. Abdel4C. G. Rivera5Division of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USADepartment of Pharmacy, Mayo Clinic, Rochester, MN 55905, USADivision of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USADivision of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USADepartment of Orthopedic Surgery, Mayo Clinic, Rochester, MN 55905, USADepartment of Pharmacy, Mayo Clinic, Rochester, MN 55905, USA<p>High-dose liquid antibiotics are uncommon in bone cement. We present a case series of patients in which up to 16 mL of liquid amikacin (250 mg mL<span class="inline-formula"><sup>−1</sup></span>) was successfully incorporated into bone cement to treat periprosthetic joint infections. We did not observe adverse drug reactions definitively attributed to its use.</p>https://jbji.copernicus.org/articles/6/147/2021/jbji-6-147-2021.pdf |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
D. B. G. Tai N. J. Brinkman O. Abu Saleh D. R. Osmon M. P. Abdel C. G. Rivera |
spellingShingle |
D. B. G. Tai N. J. Brinkman O. Abu Saleh D. R. Osmon M. P. Abdel C. G. Rivera Safety and tolerability of liquid amikacin in antibiotic-loaded bone cement – a case series Journal of Bone and Joint Infection |
author_facet |
D. B. G. Tai N. J. Brinkman O. Abu Saleh D. R. Osmon M. P. Abdel C. G. Rivera |
author_sort |
D. B. G. Tai |
title |
Safety and tolerability of liquid amikacin in antibiotic-loaded bone cement – a case series |
title_short |
Safety and tolerability of liquid amikacin in antibiotic-loaded bone cement – a case series |
title_full |
Safety and tolerability of liquid amikacin in antibiotic-loaded bone cement – a case series |
title_fullStr |
Safety and tolerability of liquid amikacin in antibiotic-loaded bone cement – a case series |
title_full_unstemmed |
Safety and tolerability of liquid amikacin in antibiotic-loaded bone cement – a case series |
title_sort |
safety and tolerability of liquid amikacin in antibiotic-loaded bone cement – a case series |
publisher |
Copernicus Publications |
series |
Journal of Bone and Joint Infection |
issn |
2206-3552 |
publishDate |
2021-04-01 |
description |
<p>High-dose liquid antibiotics are uncommon in bone cement.
We present a case series of patients in which up to 16 mL of liquid amikacin (250 mg mL<span class="inline-formula"><sup>−1</sup></span>) was successfully incorporated into bone cement to treat periprosthetic joint infections. We did not observe adverse drug reactions
definitively attributed to its use.</p> |
url |
https://jbji.copernicus.org/articles/6/147/2021/jbji-6-147-2021.pdf |
work_keys_str_mv |
AT dbgtai safetyandtolerabilityofliquidamikacininantibioticloadedbonecementacaseseries AT njbrinkman safetyandtolerabilityofliquidamikacininantibioticloadedbonecementacaseseries AT oabusaleh safetyandtolerabilityofliquidamikacininantibioticloadedbonecementacaseseries AT drosmon safetyandtolerabilityofliquidamikacininantibioticloadedbonecementacaseseries AT mpabdel safetyandtolerabilityofliquidamikacininantibioticloadedbonecementacaseseries AT cgrivera safetyandtolerabilityofliquidamikacininantibioticloadedbonecementacaseseries |
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1721507760560930816 |