Safety and tolerability of liquid amikacin in antibiotic-loaded bone cement – a case series

<p>High-dose liquid antibiotics are uncommon in bone cement. We present a case series of patients in which up to 16 mL of liquid amikacin (250 mg mL<span class="inline-formula"><sup>−1</sup></span>) was successfully incorporated into bone cement to treat perip...

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Main Authors: D. B. G. Tai, N. J. Brinkman, O. Abu Saleh, D. R. Osmon, M. P. Abdel, C. G. Rivera
Format: Article
Language:English
Published: Copernicus Publications 2021-04-01
Series:Journal of Bone and Joint Infection
Online Access:https://jbji.copernicus.org/articles/6/147/2021/jbji-6-147-2021.pdf
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spelling doaj-fb9189e986d141e9ab93c4d78c3b1c022021-04-26T06:32:28ZengCopernicus PublicationsJournal of Bone and Joint Infection2206-35522021-04-01614715010.5194/jbji-6-147-2021Safety and tolerability of liquid amikacin in antibiotic-loaded bone cement – a case seriesD. B. G. Tai0N. J. Brinkman1O. Abu Saleh2D. R. Osmon3M. P. Abdel4C. G. Rivera5Division of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USADepartment of Pharmacy, Mayo Clinic, Rochester, MN 55905, USADivision of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USADivision of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USADepartment of Orthopedic Surgery, Mayo Clinic, Rochester, MN 55905, USADepartment of Pharmacy, Mayo Clinic, Rochester, MN 55905, USA<p>High-dose liquid antibiotics are uncommon in bone cement. We present a case series of patients in which up to 16 mL of liquid amikacin (250 mg mL<span class="inline-formula"><sup>−1</sup></span>) was successfully incorporated into bone cement to treat periprosthetic joint infections. We did not observe adverse drug reactions definitively attributed to its use.</p>https://jbji.copernicus.org/articles/6/147/2021/jbji-6-147-2021.pdf
collection DOAJ
language English
format Article
sources DOAJ
author D. B. G. Tai
N. J. Brinkman
O. Abu Saleh
D. R. Osmon
M. P. Abdel
C. G. Rivera
spellingShingle D. B. G. Tai
N. J. Brinkman
O. Abu Saleh
D. R. Osmon
M. P. Abdel
C. G. Rivera
Safety and tolerability of liquid amikacin in antibiotic-loaded bone cement – a case series
Journal of Bone and Joint Infection
author_facet D. B. G. Tai
N. J. Brinkman
O. Abu Saleh
D. R. Osmon
M. P. Abdel
C. G. Rivera
author_sort D. B. G. Tai
title Safety and tolerability of liquid amikacin in antibiotic-loaded bone cement – a case series
title_short Safety and tolerability of liquid amikacin in antibiotic-loaded bone cement – a case series
title_full Safety and tolerability of liquid amikacin in antibiotic-loaded bone cement – a case series
title_fullStr Safety and tolerability of liquid amikacin in antibiotic-loaded bone cement – a case series
title_full_unstemmed Safety and tolerability of liquid amikacin in antibiotic-loaded bone cement – a case series
title_sort safety and tolerability of liquid amikacin in antibiotic-loaded bone cement – a case series
publisher Copernicus Publications
series Journal of Bone and Joint Infection
issn 2206-3552
publishDate 2021-04-01
description <p>High-dose liquid antibiotics are uncommon in bone cement. We present a case series of patients in which up to 16 mL of liquid amikacin (250 mg mL<span class="inline-formula"><sup>−1</sup></span>) was successfully incorporated into bone cement to treat periprosthetic joint infections. We did not observe adverse drug reactions definitively attributed to its use.</p>
url https://jbji.copernicus.org/articles/6/147/2021/jbji-6-147-2021.pdf
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