Neuroprotection by Endoplasmic Reticulum Stress-Induced HRD1 and Chaperones: Possible Therapeutic Targets for Alzheimer’s and Parkinson’s Disease

Neuroprotection by Endoplasmic Reticulum Stress-Induced HRD1 and Chaperones: Possible Therapeutic Targets for Alzheimer’s and Parkinson’s Disease

Alzheimer’s disease (AD) and Parkinson’s disease (PD) are neurodegenerative disorders with a severe medical and social impact. Further insights from clinical and scientific studies are essential to develop effective therapies. Various stresses on the endoplasmic reticulum (ER) cause unfolded/misfold...

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Bibliographic Details
Main Authors: Jun Nomura, Toru Hosoi, Masayuki Kaneko, Koichiro Ozawa, Akinori Nishi, Yasuyuki Nomura
Format: Article
Language:English
Published: MDPI AG 2016-08-01
Series:Medical Sciences
Subjects:
endoplasmic reticulum
unfolded protein responses
HRD1
molecular chaperone
degradation/refolding of misfolded proteins
Alzheimer’s disease
Parkinson’s disease
therapeutic development
Online Access:http://www.mdpi.com/2076-3271/4/3/14

Internet

http://www.mdpi.com/2076-3271/4/3/14

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