Endogenous H2S-Triggered In Situ Synthesis of NIR-II-Emitting Nanoprobe for In Vivo Intelligently Lighting Up Colorectal Cancer

Endogenous H2S-Triggered In Situ Synthesis of NIR-II-Emitting Nanoprobe for In Vivo Intelligently Lighting Up Colorectal Cancer

Summary: Overexpression of endogenous H2S is one of the key characteristic in colon cancer. However, developing endogenous H2S-activated optical probes for specific diagnosis of colorectal cancer is rarely explored. Herein, an in situ H2S-activatable second near-infrared (NIR-II)-emitting nanoprobe...

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Main Authors: Zhiming Deng, Mingyang Jiang, Youbin Li, Hongrong Liu, Songjun Zeng, Jianhua Hao
Format: Article
Language:English
Published: Elsevier 2019-07-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004219302172
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spelling doaj-fb8e90d072a4458ca1c583dc801284162020-11-25T01:09:09ZengElsevieriScience2589-00422019-07-0117217224Endogenous H2S-Triggered In Situ Synthesis of NIR-II-Emitting Nanoprobe for In Vivo Intelligently Lighting Up Colorectal CancerZhiming Deng0Mingyang Jiang1Youbin Li2Hongrong Liu3Songjun Zeng4Jianhua Hao5School of Physics and Electronics and Key Laboratory of Low-dimensional Quantum Structures and Quantum Control of the Ministry of Education, Synergetic Innovation Center for Quantum Effects and Applications, Hunan Normal University, Changsha, Hunan 410081, ChinaSchool of Physics and Electronics and Key Laboratory of Low-dimensional Quantum Structures and Quantum Control of the Ministry of Education, Synergetic Innovation Center for Quantum Effects and Applications, Hunan Normal University, Changsha, Hunan 410081, ChinaSchool of Physics and Electronics and Key Laboratory of Low-dimensional Quantum Structures and Quantum Control of the Ministry of Education, Synergetic Innovation Center for Quantum Effects and Applications, Hunan Normal University, Changsha, Hunan 410081, ChinaSchool of Physics and Electronics and Key Laboratory of Low-dimensional Quantum Structures and Quantum Control of the Ministry of Education, Synergetic Innovation Center for Quantum Effects and Applications, Hunan Normal University, Changsha, Hunan 410081, ChinaSchool of Physics and Electronics and Key Laboratory of Low-dimensional Quantum Structures and Quantum Control of the Ministry of Education, Synergetic Innovation Center for Quantum Effects and Applications, Hunan Normal University, Changsha, Hunan 410081, China; Corresponding authorDepartment of Applied Physics, The Hong Kong Polytechnic University, Hong Kong, China; Corresponding authorSummary: Overexpression of endogenous H2S is one of the key characteristic in colon cancer. However, developing endogenous H2S-activated optical probes for specific diagnosis of colorectal cancer is rarely explored. Herein, an in situ H2S-activatable second near-infrared (NIR-II)-emitting nanoprobe based on Ag-chicken egg white (Ag-CEW) complex for intelligently lighting up colorectal cancer was explored. The designed Ag-CEW complex holds efficient NIR-II emission of 1,000–1,400 nm via endogenous H2S-induced in situ chemical reaction to form Ag2S quantum dots (QDs). After reaction, the designed Ag-CEW complex with high photo-stability and biocompatibility was successfully used for NIR-II imaging-guided specific visualization and precise location of colorectal cancer via endogenous H2S activation. Therefore, our findings provide a new route for specifically targeting diagnosis of colon cancer based on the in situ-activatable NIR-II probe. : Optical Imaging; Biomolecules; Cancer Subject Areas: Optical Imaging, Biomolecules, Cancerhttp://www.sciencedirect.com/science/article/pii/S2589004219302172
collection DOAJ
language English
format Article
sources DOAJ
author Zhiming Deng
Mingyang Jiang
Youbin Li
Hongrong Liu
Songjun Zeng
Jianhua Hao
spellingShingle Zhiming Deng
Mingyang Jiang
Youbin Li
Hongrong Liu
Songjun Zeng
Jianhua Hao
Endogenous H2S-Triggered In Situ Synthesis of NIR-II-Emitting Nanoprobe for In Vivo Intelligently Lighting Up Colorectal Cancer
iScience
author_facet Zhiming Deng
Mingyang Jiang
Youbin Li
Hongrong Liu
Songjun Zeng
Jianhua Hao
author_sort Zhiming Deng
title Endogenous H2S-Triggered In Situ Synthesis of NIR-II-Emitting Nanoprobe for In Vivo Intelligently Lighting Up Colorectal Cancer
title_short Endogenous H2S-Triggered In Situ Synthesis of NIR-II-Emitting Nanoprobe for In Vivo Intelligently Lighting Up Colorectal Cancer
title_full Endogenous H2S-Triggered In Situ Synthesis of NIR-II-Emitting Nanoprobe for In Vivo Intelligently Lighting Up Colorectal Cancer
title_fullStr Endogenous H2S-Triggered In Situ Synthesis of NIR-II-Emitting Nanoprobe for In Vivo Intelligently Lighting Up Colorectal Cancer
title_full_unstemmed Endogenous H2S-Triggered In Situ Synthesis of NIR-II-Emitting Nanoprobe for In Vivo Intelligently Lighting Up Colorectal Cancer
title_sort endogenous h2s-triggered in situ synthesis of nir-ii-emitting nanoprobe for in vivo intelligently lighting up colorectal cancer
publisher Elsevier
series iScience
issn 2589-0042
publishDate 2019-07-01
description Summary: Overexpression of endogenous H2S is one of the key characteristic in colon cancer. However, developing endogenous H2S-activated optical probes for specific diagnosis of colorectal cancer is rarely explored. Herein, an in situ H2S-activatable second near-infrared (NIR-II)-emitting nanoprobe based on Ag-chicken egg white (Ag-CEW) complex for intelligently lighting up colorectal cancer was explored. The designed Ag-CEW complex holds efficient NIR-II emission of 1,000–1,400 nm via endogenous H2S-induced in situ chemical reaction to form Ag2S quantum dots (QDs). After reaction, the designed Ag-CEW complex with high photo-stability and biocompatibility was successfully used for NIR-II imaging-guided specific visualization and precise location of colorectal cancer via endogenous H2S activation. Therefore, our findings provide a new route for specifically targeting diagnosis of colon cancer based on the in situ-activatable NIR-II probe. : Optical Imaging; Biomolecules; Cancer Subject Areas: Optical Imaging, Biomolecules, Cancer
url http://www.sciencedirect.com/science/article/pii/S2589004219302172
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AT mingyangjiang endogenoush2striggeredinsitusynthesisofniriiemittingnanoprobeforinvivointelligentlylightingupcolorectalcancer
AT youbinli endogenoush2striggeredinsitusynthesisofniriiemittingnanoprobeforinvivointelligentlylightingupcolorectalcancer
AT hongrongliu endogenoush2striggeredinsitusynthesisofniriiemittingnanoprobeforinvivointelligentlylightingupcolorectalcancer
AT songjunzeng endogenoush2striggeredinsitusynthesisofniriiemittingnanoprobeforinvivointelligentlylightingupcolorectalcancer
AT jianhuahao endogenoush2striggeredinsitusynthesisofniriiemittingnanoprobeforinvivointelligentlylightingupcolorectalcancer
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