Remodeling the Bone Marrow Microenvironment – A Proposal for Targeting Pro-inflammatory Contributors in MPN

Remodeling the Bone Marrow Microenvironment – A Proposal for Targeting Pro-inflammatory Contributors in MPN

Philadelphia-negative myeloproliferative neoplasms (MPN) are malignant bone marrow (BM) disorders, typically arising from a single somatically mutated hematopoietic stem cell. The most commonly mutated genes, JAK2, CALR, and MPL lead to constitutively active JAK-STAT signaling. Common clinical featu...

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Bibliographic Details
Main Authors: Jonas Samuel Jutzi, Ann Mullally
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Immunology
Subjects:
MPN
JAK2
CALR
MPL
inflammation
megakaryocytes
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.02093/full
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spelling doaj-fb8a6f5ca6ac424d8f436a3a791555cb2020-11-25T03:53:41ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-08-011110.3389/fimmu.2020.02093561892Remodeling the Bone Marrow Microenvironment – A Proposal for Targeting Pro-inflammatory Contributors in MPNJonas Samuel Jutzi0Ann Mullally1Ann Mullally2Ann Mullally3Division of Hematology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United StatesDivision of Hematology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United StatesDepartment of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, United StatesCancer Program, Broad Institute, Cambridge, MA, United StatesPhiladelphia-negative myeloproliferative neoplasms (MPN) are malignant bone marrow (BM) disorders, typically arising from a single somatically mutated hematopoietic stem cell. The most commonly mutated genes, JAK2, CALR, and MPL lead to constitutively active JAK-STAT signaling. Common clinical features include myeloproliferation, splenomegaly and constitutional symptoms. This review covers the contributions of cellular components of MPN pathology (e.g., monocytes, megakaryocytes, and mesenchymal stromal cells) as well as cytokines and soluble mediators to the development of myelofibrosis (MF) and highlights recent therapeutic advances. These findings outline the importance of malignant and non-malignant BM constituents to the pathogenesis and treatment of MF.https://www.frontiersin.org/article/10.3389/fimmu.2020.02093/fullMPNJAK2CALRMPLinflammationmegakaryocytes
collection DOAJ
language English
format Article
sources DOAJ
author Jonas Samuel Jutzi
Ann Mullally
Ann Mullally
Ann Mullally
spellingShingle Jonas Samuel Jutzi
Ann Mullally
Ann Mullally
Ann Mullally
Remodeling the Bone Marrow Microenvironment – A Proposal for Targeting Pro-inflammatory Contributors in MPN
Frontiers in Immunology
MPN
JAK2
CALR
MPL
inflammation
megakaryocytes
author_facet Jonas Samuel Jutzi
Ann Mullally
Ann Mullally
Ann Mullally
author_sort Jonas Samuel Jutzi
title Remodeling the Bone Marrow Microenvironment – A Proposal for Targeting Pro-inflammatory Contributors in MPN
title_short Remodeling the Bone Marrow Microenvironment – A Proposal for Targeting Pro-inflammatory Contributors in MPN
title_full Remodeling the Bone Marrow Microenvironment – A Proposal for Targeting Pro-inflammatory Contributors in MPN
title_fullStr Remodeling the Bone Marrow Microenvironment – A Proposal for Targeting Pro-inflammatory Contributors in MPN
title_full_unstemmed Remodeling the Bone Marrow Microenvironment – A Proposal for Targeting Pro-inflammatory Contributors in MPN
title_sort remodeling the bone marrow microenvironment – a proposal for targeting pro-inflammatory contributors in mpn
publisher Frontiers Media S.A.
series Frontiers in Immunology
issn 1664-3224
publishDate 2020-08-01
description Philadelphia-negative myeloproliferative neoplasms (MPN) are malignant bone marrow (BM) disorders, typically arising from a single somatically mutated hematopoietic stem cell. The most commonly mutated genes, JAK2, CALR, and MPL lead to constitutively active JAK-STAT signaling. Common clinical features include myeloproliferation, splenomegaly and constitutional symptoms. This review covers the contributions of cellular components of MPN pathology (e.g., monocytes, megakaryocytes, and mesenchymal stromal cells) as well as cytokines and soluble mediators to the development of myelofibrosis (MF) and highlights recent therapeutic advances. These findings outline the importance of malignant and non-malignant BM constituents to the pathogenesis and treatment of MF.
topic MPN
JAK2
CALR
MPL
inflammation
megakaryocytes
url https://www.frontiersin.org/article/10.3389/fimmu.2020.02093/full
work_keys_str_mv AT jonassamueljutzi remodelingthebonemarrowmicroenvironmentaproposalfortargetingproinflammatorycontributorsinmpn
AT annmullally remodelingthebonemarrowmicroenvironmentaproposalfortargetingproinflammatorycontributorsinmpn
AT annmullally remodelingthebonemarrowmicroenvironmentaproposalfortargetingproinflammatorycontributorsinmpn
AT annmullally remodelingthebonemarrowmicroenvironmentaproposalfortargetingproinflammatorycontributorsinmpn
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