Low-dose HDACi potentiates anti-tumor activity of macrophages in immunotherapy
The success of checkpoint immunotherapy has created optimism that cancer may be curable. However, not all patients respond, resistance is common and many patients relapse owing to immune escape. We demonstrate that HDAC inhibition not only decreases the trafficking of myeloid-derived suppressor cell...
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| Format: | Article |
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Taylor & Francis Group
2021-01-01
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| Series: | OncoImmunology |
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| Online Access: | http://dx.doi.org/10.1080/2162402X.2021.1935668 |
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Article |
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doaj-fb8947acfdf84dfaad4c20eeb144c0502021-06-11T09:33:08ZengTaylor & Francis GroupOncoImmunology2162-402X2021-01-0110110.1080/2162402X.2021.19356681935668Low-dose HDACi potentiates anti-tumor activity of macrophages in immunotherapyXiaolei Li0Hanren Dai1Hua Wang2The First Affiliated Hospital of Anhui Medical UniversityThe First Affiliated Hospital of Anhui Medical UniversityThe First Affiliated Hospital of Anhui Medical UniversityThe success of checkpoint immunotherapy has created optimism that cancer may be curable. However, not all patients respond, resistance is common and many patients relapse owing to immune escape. We demonstrate that HDAC inhibition not only decreases the trafficking of myeloid-derived suppressor cells (MDSCs) into tumors but also potentiates tumor-associated macrophages (TAMs) to specify anti-tumoral phenotype and bolster T cells activation within the tumor microenvironment (TME).http://dx.doi.org/10.1080/2162402X.2021.1935668hdacitumor-associated macrophagestumor microenvironmentcancer immunotherapy |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Xiaolei Li Hanren Dai Hua Wang |
| spellingShingle |
Xiaolei Li Hanren Dai Hua Wang Low-dose HDACi potentiates anti-tumor activity of macrophages in immunotherapy OncoImmunology hdaci tumor-associated macrophages tumor microenvironment cancer immunotherapy |
| author_facet |
Xiaolei Li Hanren Dai Hua Wang |
| author_sort |
Xiaolei Li |
| title |
Low-dose HDACi potentiates anti-tumor activity of macrophages in immunotherapy |
| title_short |
Low-dose HDACi potentiates anti-tumor activity of macrophages in immunotherapy |
| title_full |
Low-dose HDACi potentiates anti-tumor activity of macrophages in immunotherapy |
| title_fullStr |
Low-dose HDACi potentiates anti-tumor activity of macrophages in immunotherapy |
| title_full_unstemmed |
Low-dose HDACi potentiates anti-tumor activity of macrophages in immunotherapy |
| title_sort |
low-dose hdaci potentiates anti-tumor activity of macrophages in immunotherapy |
| publisher |
Taylor & Francis Group |
| series |
OncoImmunology |
| issn |
2162-402X |
| publishDate |
2021-01-01 |
| description |
The success of checkpoint immunotherapy has created optimism that cancer may be curable. However, not all patients respond, resistance is common and many patients relapse owing to immune escape. We demonstrate that HDAC inhibition not only decreases the trafficking of myeloid-derived suppressor cells (MDSCs) into tumors but also potentiates tumor-associated macrophages (TAMs) to specify anti-tumoral phenotype and bolster T cells activation within the tumor microenvironment (TME). |
| topic |
hdaci tumor-associated macrophages tumor microenvironment cancer immunotherapy |
| url |
http://dx.doi.org/10.1080/2162402X.2021.1935668 |
| work_keys_str_mv |
AT xiaoleili lowdosehdacipotentiatesantitumoractivityofmacrophagesinimmunotherapy AT hanrendai lowdosehdacipotentiatesantitumoractivityofmacrophagesinimmunotherapy AT huawang lowdosehdacipotentiatesantitumoractivityofmacrophagesinimmunotherapy |
| _version_ |
1721382727279706112 |