Cdk5 Inhibitory Peptide Prevents Loss of Dopaminergic Neurons and Alleviates Behavioral Changes in an MPTP Induced Parkinson’s Disease Mouse Model

Cdk5 Inhibitory Peptide Prevents Loss of Dopaminergic Neurons and Alleviates Behavioral Changes in an MPTP Induced Parkinson’s Disease Mouse Model

Parkinson’s disease (PD) is one of the most affected neurodegenerative diseases in the world. Deregulation of cyclin-dependent kinase 5 (Cdk5) is believed to play an important role in neurodegenerative diseases including PD. p25 is a cleavage peptide of p35, a physiologic activator of Cdk5. p25 comb...

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Bibliographic Details
Main Authors: Rongni He, Wei Huang, Yaowei Huang, Miaojing Xu, Pingping Song, Yinwei Huang, Huifang Xie, Yafang Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Aging Neuroscience
Subjects:
AAV9
cyclin-dependent kinase 5
CIP
Parkinson’s disease
MPTP
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2018.00162/full

Internet

https://www.frontiersin.org/article/10.3389/fnagi.2018.00162/full

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