Tumor Microenvironment-Responsive Shell/Core Composite Nanoparticles for Enhanced Stability and Antitumor Efficiency Based on a pH-Triggered Charge-Reversal Mechanism

Tumor Microenvironment-Responsive Shell/Core Composite Nanoparticles for Enhanced Stability and Antitumor Efficiency Based on a pH-Triggered Charge-Reversal Mechanism

High systemic stability and effective tumor accumulation of chemotherapeutic agents are indispensable elements that determine their antitumor efficacy. PEGylation of nanoparticles (NPs) could prolong the retention time in vivo by improving their stability in circulation, but treatment suffers reduce...

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Bibliographic Details
Main Authors: Qiuhua Luo, Wen Shi, Puxiu Wang, Yu Zhang, Jia Meng, Ling Zhang
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Pharmaceutics
Subjects:
shielding system
shell/core structure
charge-reversal
pH-triggered
cancer therapy
Online Access:https://www.mdpi.com/1999-4923/13/6/895

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