DHA induces ER stress and growth arrest in human colon cancer cells: associations with cholesterol and calcium homeostasis *s⃞

DHA induces ER stress and growth arrest in human colon cancer cells: associations with cholesterol and calcium homeostasis *s⃞

Polyunsaturated fatty acids (PUFAs) are normal constituents of the diet, but have properties different from other fatty acids (e.g., through generation of signaling molecules). N-3 PUFAs reduce cancer cell growth, but no unified mechanism has been identified. We show that docosahexaenoic acid (DHA;...

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Bibliographic Details
Main Authors: Caroline Hild Jakobsen, Gro Leite Størvold, Hilde Bremseth, Turid Follestad, Kristin Sand, Merete Mack, Karina Standahl Olsen, Anne Gøril Lundemo, Jens Gustav Iversen, Hans Einar Krokan, Svanhild Arentz Schønberg
Format: Article
Language:English
Published: Elsevier 2008-10-01
Series:Journal of Lipid Research
Subjects:
gene expression
phosphorylated eIF2α
antioxidant response
heat shock response
cytosolic free Ca2+
cell cycle
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520346320

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