A small molecule SMAC mimic LBW242 potentiates TRAIL- and anticancer drug-mediated cell death of ovarian cancer cells.

A small molecule SMAC mimic LBW242 potentiates TRAIL- and anticancer drug-mediated cell death of ovarian cancer cells.

BACKGROUND: Ovarian cancer remains a leading cause of death in women and development of new therapies is essential. Second mitochondria derived activator of caspase (SMAC) has been described to sensitize for apoptosis. We have explored the pro-apoptotic activity of LBW242, a mimic of SMAC/DIABLO, on...

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Main Authors: Eleonora Petrucci, Luca Pasquini, Manuela Bernabei, Ernestina Saulle, Mauro Biffoni, Fabio Accarpio, Simone Sibio, Angelo Di Giorgio, Violante Di Donato, Assunta Casorelli, Pierluigi Benedetti-Panici, Ugo Testa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3338831?pdf=render

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