Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse

Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse

To address the long-known relationship between supernumerary centrosomes and cancer, we have generated a transgenic mouse that permits inducible expression of the master regulator of centriole duplication, Polo-like-kinase-4 (Plk4). Over-expression of Plk4 from this transgene advances the onset of t...

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Bibliographic Details
Main Authors: Paula A. Coelho, Leah Bury, Marta N. Shahbazi, Kifayathullah Liakath-Ali, Peri H. Tate, Sam Wormald, Christopher J. Hindley, Meritxell Huch, Joy Archer, William C. Skarnes, Magdalena Zernicka-Goetz, David M. Glover
Format: Article
Language:English
Published: The Royal Society 2015-01-01
Series:Open Biology
Subjects:
primary cilia
polo-like-kinase-4
skin
tumour development
centrosome amplification
pancreas
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.150209

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https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.150209

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