Drugs acting on central nervous system (CNS) targets as leads for non-CNS targets [v2; ref status: indexed, http://f1000r.es/35d]
Innovative drug discovery approaches are currently needed to rejuvenate the shrinking product pipelines of the pharmaceutical companies across the globe. Here a theme is presented – the use of central nervous system (CNS) drugs as leads for non-CNS targets. The approach is related to the use of exis...
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2014-03-01
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| Series: | F1000Research |
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| Online Access: | http://f1000research.com/articles/3-40/v2 |
| Summary: | Innovative drug discovery approaches are currently needed to rejuvenate the shrinking product pipelines of the pharmaceutical companies across the globe. Here a theme is presented – the use of central nervous system (CNS) drugs as leads for non-CNS targets. The approach is related to the use of existing drugs for new indications. Suitable chemical modifications of the CNS drugs abolish their CNS penetration. These novel analogs may then be screened for activity against non-CNS targets. Careful selection of the appropriate structural modifications remains the key to success. |
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| ISSN: | 2046-1402 |