The GARP Complex Is Involved in Intracellular Cholesterol Transport via Targeting NPC2 to Lysosomes

The GARP Complex Is Involved in Intracellular Cholesterol Transport via Targeting NPC2 to Lysosomes

Proper intracellular cholesterol trafficking is critical for cellular function. Two lysosome-resident proteins, NPC1 and NPC2, mediate the egress of low-density lipoprotein-derived cholesterol from lysosomes. However, other proteins involved in this process remain largely unknown. Through amphoteric...

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Bibliographic Details
Main Authors: Jian Wei, Ying-Yu Zhang, Jie Luo, Ju-Qiong Wang, Yu-Xia Zhou, Hong-Hua Miao, Xiong-Jie Shi, Yu-Xiu Qu, Jie Xu, Bo-Liang Li, Bao-Liang Song
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Cell Reports
Subjects:
intracellular cholesterol transport
Niemann-Pick Type C disease
NPC
NPC1/2
vacuolar protein sorting 53
VPS53
Golgi-associated retrograde protein complex
GARP
lysosome
cation-independent mannose 6-phosphate receptor
CI-MPR
trans-Golgi network
TGN
retrograde transport
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717308082

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