814 MCLA-145 (CD137xPD-L1): a potent CD137 agonist and immune checkpoint inhibitor that that does not show signs of peripheral toxicity

814 MCLA-145 (CD137xPD-L1): a potent CD137 agonist and immune checkpoint inhibitor that that does not show signs of peripheral toxicity

Bibliographic Details
Main Authors:	Mark Throsby, Arpita Mondal, Kees Bol, Wilfred Marissen, Jeroen Elaissais-Schaap, Paul Tacken, Steef Engels, Liang-Chuan Wang, Alan Roberts, Patrick Mayes, Cecile Geuijen
Format:	Article
Language:	English
Published:	BMJ Publishing Group 2020-11-01
Series:	Journal for ImmunoTherapy of Cancer

Similar Items

820 MCLA-145 is a bispecific IgG1 antibody that inhibits PD-1/PD-L1 signaling while simultaneously activating CD137 signaling on T cells
by: Jing Zhou, et al.
Published: (2020-11-01)

Regulatory T Cells Inhibit T Cell Activity by Downregulating CD137 Ligand via CD137 Trogocytosis
by: Khang Luu, et al.
Published: (2021-02-01)

The Murine CD137/CD137 Ligand Signalosome: A Signal Platform Generating Signal Complexity
by: Beom K. Choi, et al.
Published: (2020-12-01)

The Progress of Investigating the CD137-CD137L Axis as a Potential Target for Systemic Lupus Erythematosus
by: Anselm Mak, et al.
Published: (2019-09-01)

CD137-CD137L interaction regulates atherosclerosis via cyclophilin A in apolipoprotein E-deficient mice.
by: Yuefeng Li, et al.
Published: (2014-01-01)

Identification of CD137-Expressing B Cells in Multiple Sclerosis Which Secrete IL-6 Upon Engagement by CD137 Ligand
by: Hiu Yi Wong, et al.
Published: (2020-11-01)

A human CD137×PD-L1 bispecific antibody promotes anti-tumor immunity via context-dependent T cell costimulation and checkpoint blockade
by: Cecile Geuijen, et al.
Published: (2021-07-01)

CD137 expression in cancer cells: regulation and significance
by: Christophe Glorieux, et al.
Published: (2019-11-01)

An Update on Anti-CD137 Antibodies in Immunotherapies for Cancer
by: Dinh-Toi Chu, et al.
Published: (2019-04-01)

Contributions of Costimulatory Molecule CD137 in Endothelial Cells
by: Wei Yuan, et al.
Published: (2021-06-01)

647 Evaluation of efficacy and toxicity of CD137 immunotherapy with urelumab-mIgG1 chimeric antibody in CD137 HuGEMM™
by: Daniel He, et al.
Published: (2020-11-01)

Untersuchungen zu den kostimulatorischen Signalwegen PD-1/PD-L1 und CD137/CD137L beim kolorektalen Karzinom
by: Wagner, Martin
Published: (2019)

CD137<sup>+</sup> T-Cells: Protagonists of the Immunotherapy Revolution
by: Alessio Ugolini, et al.
Published: (2021-01-01)

Depletion of Alloreactive T-Cells by Anti-CD137-Saporin Immunotoxin
by: Sang C. Lee, et al.
Published: (2015-06-01)

Expression of CD152 and CD137 on T regulatory cells in rhinitis and bronchial asthma patients
by: Enrique Rojas-Ramos, et al.
Published: (2015-04-01)

Species difference of CD137 ligand signaling in human and murine monocytes.
by: Qianqiao Tang, et al.
Published: (2011-01-01)

Immunotherapy of melanoma with the immune costimulatory monoclonal antibodies targeting CD137
by: Li SY, et al.
Published: (2013-09-01)

Role of ADAM10 and ADAM17 in Regulating CD137 Function
by: Jana Seidel, et al.
Published: (2021-03-01)

377 AGEN2373 is a CD137 agonist antibody designed to leverage optimal CD137 and FcγR co-targeting to promote antitumor immunologic effects
by: Nicholas Wilson, et al.
Published: (2020-11-01)

Development of a Bispecific Antibody Targeting CD30 and CD137 on Hodgkin and Reed-Sternberg Cells
by: Sakthi Rajendran, et al.
Published: (2019-09-01)

Anticancer immunity induced by a synthetic tumor-targeted CD137 agonist
by: Sailaja Battula, et al.
Published: (2021-01-01)

CD137 (4-1BB) Signalosome: Complexity Is a Matter of TRAFs
by: Juan M. Zapata, et al.
Published: (2018-11-01)

CD137L-DCs, Potent Immune-Stimulators—History, Characteristics, and Perspectives
by: Qun Zeng, et al.
Published: (2019-10-01)

CD137 facilitates the resolution of acute DSS-induced colonic inflammation in mice.
by: Julia M Martínez Gómez, et al.
Published: (2013-01-01)

CD137 Signaling Regulates Acute Colitis via RALDH2-Expressing CD11b−CD103+ DCs
by: Jing Jin, et al.
Published: (2020-03-01)

Targeting 4-1BB (CD137) to enhance CD8 T cell responses with poxviruses and viral antigens
by: Yuan eZhao, et al.
Published: (2012-11-01)

Correction: CD137 Facilitates the Resolution of Acute DSS-Induced Colonic Inflammation in Mice
by: Julia M. Martínez Gómez, et al.
Published: (2014-01-01)

Ectopic CD137 expression by rhabdomyosarcoma provides selection advantages but allows immunotherapeutic targeting
by: Kang Yi Lee, et al.
Published: (2021-01-01)

Regulation of CD137 expression through K-Ras signaling in pancreatic cancer cells
by: Christophe Glorieux, et al.
Published: (2019-07-01)

Human and mouse CD137 have predominantly different binding CRDs to their respective ligands.
by: Ling Yi, et al.
Published: (2014-01-01)

Bayesian approach to model CD137 signaling in human M. tuberculosis in vitro responses.
by: Darío A Fernández Do Porto, et al.
Published: (2013-01-01)

Soluble CD137 Ameliorates Acute Type 1 Diabetes by Inducing T Cell Anergy
by: Arata Itoh, et al.
Published: (2019-11-01)

Deletion of CD137 Ligand Exacerbates Renal and Cutaneous but Alleviates Cerebral Manifestations in Lupus
by: Anselm Mak, et al.
Published: (2019-06-01)

Increased Akt-Driven Glycolysis Is the Basis for the Higher Potency of CD137L-DCs
by: Qun Zeng, et al.
Published: (2019-04-01)

Correction: CD137 Facilitates the Resolution of Acute DSS-Induced Colonic Inflammation in Mice.
by: Julia M. Martínez Gómez, et al.
Published: (2014-01-01)

THE OBJECT MWC 137
by: L. N. Kondratyeva
Published: (2007-12-01)

Spiritan News 137
by: Holy Ghost Fathers

Routes of delivery for CpG and anti-CD137 for the treatment of orthotopic kidney tumors in mice.
by: Jennifer A Westwood, et al.
Published: (2014-01-01)

Inhibition of proliferation and induction of apoptosis in multiple myeloma cell lines by CD137 ligand signaling.
by: Charles Gullo, et al.
Published: (2010-01-01)

Analysis of CD137L and IL-17 Expression in Tumor Tissue as Prognostic Indicators for Gliblastoma
by: Xiangli Cui, Zhiqin Xu, Zhigang Zhao, Dali Sui, Xiaohui Ren, Qiming Huang, Jiazhen Qin, Limin Hao, Zhenguang Wang, Li Shen, Song Lin
Published: (2013-01-01)

Cannot write session to /tmp/vufind_sessions/sess_vd58gmnadon5c687m30oddt8eu