The use of one-stage meta-analytic method based on individual participant data for binary adverse events under the rule of three: a simulation study
Objective In evidence synthesis practice, dealing with binary rare adverse events (AEs) is a challenging problem. The pooled estimates for rare AEs through traditional inverse variance (IV), Mantel-Haenszel (MH), and Yusuf-Peto (Peto) methods are suboptimal, as the biases tend to be large. We propos...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
PeerJ Inc.
2019-01-01
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| Series: | PeerJ |
| Subjects: | |
| Online Access: | https://peerj.com/articles/6295.pdf |