Advances in Gene Delivery Methods to Label and Modulate Activity of Upper Motor Neurons: Implications for Amyotrophic Lateral Sclerosis

Advances in Gene Delivery Methods to Label and Modulate Activity of Upper Motor Neurons: Implications for Amyotrophic Lateral Sclerosis

The selective degeneration of both upper motor neurons (UMNs) and lower motor neurons (LMNs) is the pathological hallmark of amyotrophic lateral sclerosis (ALS). Unlike the simple organisation of LMNs in the brainstem and spinal cord, UMNs are embedded in the complex cytoarchitecture of the primary...

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Bibliographic Details
Main Authors: Mouna Haidar, Aida Viden, Bradley J. Turner
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Brain Sciences
Subjects:
amyotrophic lateral sclerosis
motor cortex
upper motor neurons
retrograde tracing
viral vectors
reporter mouse models
Online Access:https://www.mdpi.com/2076-3425/11/9/1112

Internet

https://www.mdpi.com/2076-3425/11/9/1112

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