The role of mycobiota-genotype association in inflammatory bowel diseases: a narrative review

• Main Authors: Elaheh Mahmoudi, Sayed-Hamidreza Mozhgani, Niusha Sharifinejad
• Format: Article
• Language: English
• Published: BMC 2021-05-01
• Series: Gut Pathogens
• Subjects: Inflammatory bowel disease; IBD; Fungal microbiota; Intestinal mycobiota; Single nucleotide polymorphisms; SNPs
• Online Access: https://doi.org/10.1186/s13099-021-00426-4

Abstract Inflammatory bowel disease (IBD) is a chronic inflammatory disease affecting various parts of the gastrointestinal tract. A majority of the current evidence points out the involvement of intestinal dysbiosis in the IBD pathogenesis. Recently, the association of intestinal fungal composition With IBD susceptibility and severity has been reported. These studies suggested gene polymorphisms in the front line of host defense against intestinal microorganisms are considered to play a role in IBD pathogenesis. The studies have also detected increased susceptibility to fungal infections in patients carrying IBD-related mutations. Therefore, a literature search was conducted in related databases to review articles addressing the mycobiota-genotype association in IBD.