Targeting p35/Cdk5 signalling via CIP-peptide promotes angiogenesis in hypoxia.

Targeting p35/Cdk5 signalling via CIP-peptide promotes angiogenesis in hypoxia.

Cyclin-dependent kinase-5 (Cdk5) is over-expressed in both neurons and microvessels in hypoxic regions of stroke tissue and has a significant pathological role following hyper-phosphorylation leading to calpain-induced cell death. Here, we have identified a critical role of Cdk5 in cytoskeleton/foca...

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Main Authors: Alessandra Bosutti, Jie Qi, Roberta Pennucci, David Bolton, Sabine Matou, Kamela Ali, Li-Huei Tsai, Jerzy Krupinski, Eugene B Petcu, Joan Montaner, Raid Al Baradie, Francesca Caccuri, Arnaldo Caruso, Giulio Alessandri, Shant Kumar, Cristina Rodriguez, Jose Martinez-Gonzalez, Mark Slevin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3787057?pdf=render

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