Systemic Candesartan Treatment Modulates Behavior, Synaptic Protein Levels, and Neuroinflammation in Female Mice That Express Human APOE4

Systemic Candesartan Treatment Modulates Behavior, Synaptic Protein Levels, and Neuroinflammation in Female Mice That Express Human APOE4

Evidence suggests that angiotensin receptor blockers (ARBs) could be beneficial for Alzheimer’s disease (AD) patients independent of any effects on hypertension. However, studies in rodent models directly testing the activity of ARB treatment on behavior and AD-relevent pathology including neuroinfl...

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Bibliographic Details
Main Authors: Sarah B. Scheinman, Steve Zaldua, Adedoyin Dada, Kateryna Krochmaliuk, Katherine Dye, Felecia M. Marottoli, Gregory R. J. Thatcher, Leon M. Tai
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Neuroscience
Subjects:
angiotensin receptor blocker
ApoE4
female sex
memory
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.628403/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2021.628403/full

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