SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition
The pandemic of COVID-19, caused by SARS-CoV-2 infection, warrants immediate investigation for therapy options. Here the authors show, using epithelial and air-liquid interface cultures, that SARS-CoV-2 hijacks host cell metabolism to facilitate viral replication, and that inhibition of mTORC1, a ma...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-22166-4 |
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doaj-fb48f36f0ee14f8194aa51fcf0be0cc62021-03-28T11:11:59ZengNature Publishing GroupNature Communications2041-17232021-03-0112111010.1038/s41467-021-22166-4SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibitionPeter J. Mullen0Gustavo Garcia1Arunima Purkayastha2Nedas Matulionis3Ernst W. Schmid4Milica Momcilovic5Chandani Sen6Justin Langerman7Arunachalam Ramaiah8David B. Shackelford9Robert Damoiseaux10Samuel W. French11Kathrin Plath12Brigitte N. Gomperts13Vaithilingaraja Arumugaswami14Heather R. Christofk15Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles (UCLA)Department of Molecular and Medical Pharmacology, UCLAUCLA Children’s Discovery and Innovation Institute, Mattel Children’s Hospital UCLA, Department of Pediatrics, David Geffen School of Medicine, UCLADepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles (UCLA)Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles (UCLA)Department of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, UCLAUCLA Children’s Discovery and Innovation Institute, Mattel Children’s Hospital UCLA, Department of Pediatrics, David Geffen School of Medicine, UCLADepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles (UCLA)Department of Ecology and Evolutionary Biology, University of California, IrvineDepartment of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, UCLADepartment of Molecular and Medical Pharmacology, UCLAJonsson Comprehensive Cancer Center, UCLADepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles (UCLA)UCLA Children’s Discovery and Innovation Institute, Mattel Children’s Hospital UCLA, Department of Pediatrics, David Geffen School of Medicine, UCLADepartment of Molecular and Medical Pharmacology, UCLADepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles (UCLA)The pandemic of COVID-19, caused by SARS-CoV-2 infection, warrants immediate investigation for therapy options. Here the authors show, using epithelial and air-liquid interface cultures, that SARS-CoV-2 hijacks host cell metabolism to facilitate viral replication, and that inhibition of mTORC1, a master metabolic regulator, suppresses viral replication.https://doi.org/10.1038/s41467-021-22166-4 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Peter J. Mullen Gustavo Garcia Arunima Purkayastha Nedas Matulionis Ernst W. Schmid Milica Momcilovic Chandani Sen Justin Langerman Arunachalam Ramaiah David B. Shackelford Robert Damoiseaux Samuel W. French Kathrin Plath Brigitte N. Gomperts Vaithilingaraja Arumugaswami Heather R. Christofk |
| spellingShingle |
Peter J. Mullen Gustavo Garcia Arunima Purkayastha Nedas Matulionis Ernst W. Schmid Milica Momcilovic Chandani Sen Justin Langerman Arunachalam Ramaiah David B. Shackelford Robert Damoiseaux Samuel W. French Kathrin Plath Brigitte N. Gomperts Vaithilingaraja Arumugaswami Heather R. Christofk SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition Nature Communications |
| author_facet |
Peter J. Mullen Gustavo Garcia Arunima Purkayastha Nedas Matulionis Ernst W. Schmid Milica Momcilovic Chandani Sen Justin Langerman Arunachalam Ramaiah David B. Shackelford Robert Damoiseaux Samuel W. French Kathrin Plath Brigitte N. Gomperts Vaithilingaraja Arumugaswami Heather R. Christofk |
| author_sort |
Peter J. Mullen |
| title |
SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition |
| title_short |
SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition |
| title_full |
SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition |
| title_fullStr |
SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition |
| title_full_unstemmed |
SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition |
| title_sort |
sars-cov-2 infection rewires host cell metabolism and is potentially susceptible to mtorc1 inhibition |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-03-01 |
| description |
The pandemic of COVID-19, caused by SARS-CoV-2 infection, warrants immediate investigation for therapy options. Here the authors show, using epithelial and air-liquid interface cultures, that SARS-CoV-2 hijacks host cell metabolism to facilitate viral replication, and that inhibition of mTORC1, a master metabolic regulator, suppresses viral replication. |
| url |
https://doi.org/10.1038/s41467-021-22166-4 |
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