11-amino acid peptide imitating the structure of erythropoietin α-helix b improves endothelial function, but stimulates thrombosis in rats.

11-amino acid peptide imitating the structure of erythropoietin α-helix b improves endothelial function, but stimulates thrombosis in rats.

The aim of the study was to test whether P-αB can be positioned as a preventing and treating agent for cardiovascular diseases.Materials and methods. The study was performed on sexually mature male Wistar rats. Endothelial dysfunction was modulated by a 7-days intraperitoneal administration of L-NAM...

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Bibliographic Details
Main Authors: M. V. Korokin, V. O. Soldatov, A. A. Tietze, M. V. Golubev, A. E. Belykh, M. V. Kubekina, O. A. Puchenkova, T. A. Denisyuk, V. V. Gureyev, T. G. Pokrovskaya, O. S. Gudyrev, M. A. Zhuchenko, M. A. Zatolokina, M. V. Pokrovskiy
Format: Article
Language:Russian
Published: Pyatigorsk Medical and Pharmaceutical Institute - branch of Volgograd State Medical University 2020-01-01
Series:Farmaciâ i Farmakologiâ (Pâtigorsk)
Subjects:
atherosclerosis
erythropoietin
rats
p-αb
cibenitide
endothelium
Online Access:https://www.pharmpharm.ru/jour/article/view/550

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