Over-expression of microRNA-375 inhibits papillary thyroid carcinoma cell proliferation and induces cell apoptosis by targeting ERBB2

• Main Authors: Xin-Zheng Wang, Ya-Kai Hang, Jin-Biao Liu, Yong-Qiang Hou, Ning Wang, Ming-Jun Wang
• Format: Article
• Language: English
• Published: Elsevier 2016-02-01
• Series: Journal of Pharmacological Sciences
• Subjects: MicroRNA-375; Papillary thyroid carcinoma; ERBB2; Apoptosis
• Online Access: http://www.sciencedirect.com/science/article/pii/S1347861315002418
• ISSN: 1347-8613

MicroRNAs (miRs) played important roles in the cell proliferation, apoptosis and other biological processes in cancer. In the present study we found that miR-375 was significantly down-regulated in human papillary thyroid carcinoma (PTC) tissues and cell lines. In this study we try to investigate the biological activity of miR-375 in human PTC cells and try to find the potential target of miR-375. Our study indicated that over-expression of miR-375 could inhibit the PTC cells proliferation and this inhibition was caused by the induction of cell apoptosis. In vivo animal study indicated that over-expression of miR-375 could significantly decrease the migration and invasion of human PTC cell in vivo. These results exhibit over-expression of miR-375 in human PTC cells could inhibit the process of human PTC. Further study demonstrated ERBB2 was a direct target of miR-375, over-expression of miR-375 decrease the both mRNA and protein expression of ERBB2 in human PTC cells. These data indicate miR-375 play important roles in the process and development of human PTC. These finds suggested that appropriate application of miR-375 regulation might be a new sight for the treatment of human PTC in the future.