Relevance of TNBS-colitis in rats: a methodological study with endoscopic, histologic and Transcriptomic [corrected] characterization and correlation to IBD.

Relevance of TNBS-colitis in rats: a methodological study with endoscopic, histologic and Transcriptomic [corrected] characterization and correlation to IBD.

Rectal instillation of trinitrobenzene sulphonic acid (TNBS) in ethanol is an established model for inflammatory bowel disease (IBD). We aimed to 1) set up a TNBS-colitis protocol resulting in an endoscopic and histologic picture resembling IBD, 2) study the correlation between endoscopic, histologi...

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Main Authors: Øystein Brenna, Marianne W Furnes, Ignat Drozdov, Atle van Beelen Granlund, Arnar Flatberg, Arne K Sandvik, Rosalie T M Zwiggelaar, Ronald Mårvik, Ivar S Nordrum, Mark Kidd, Björn I Gustafsson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3561356?pdf=render

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