Single-cell RNA sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development
Midbrain dopamine (mDA) neurons are significantly associated with Parkinson’s disease and yet there is no systematic molecular classification of these heterogenous group of cells. Here authors use single cell RNA sequencing of isolated mouse neurons expressing the transcription factor Pitx3 (broad m...
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Nature Publishing Group
2019-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-08453-1 |
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doaj-fb22d9e2478a422ebc121e8f033474f42021-05-11T11:28:07ZengNature Publishing GroupNature Communications2041-17232019-02-0110111210.1038/s41467-019-08453-1Single-cell RNA sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain developmentKatarína Tiklová0Åsa K. Björklund1Laura Lahti2Alessandro Fiorenzano3Sara Nolbrant4Linda Gillberg5Nikolaos Volakakis6Chika Yokota7Markus M. Hilscher8Thomas Hauling9Fredrik Holmström10Eliza Joodmardi11Mats Nilsson12Malin Parmar13Thomas Perlmann14Ludwig Institute for Cancer ResearchDepartment of Cell and Molecular Biology, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Uppsala UniversityLudwig Institute for Cancer ResearchDevelopmental and Regenerative Neurobiology, Wallenberg Neuroscience Center, and Lund Stem Cell Centre, Department of Experimental Medical Science, Lund UniversityDevelopmental and Regenerative Neurobiology, Wallenberg Neuroscience Center, and Lund Stem Cell Centre, Department of Experimental Medical Science, Lund UniversityLudwig Institute for Cancer ResearchLudwig Institute for Cancer ResearchScience for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm UniversityScience for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm UniversityScience for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm UniversityLudwig Institute for Cancer ResearchLudwig Institute for Cancer ResearchScience for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm UniversityDevelopmental and Regenerative Neurobiology, Wallenberg Neuroscience Center, and Lund Stem Cell Centre, Department of Experimental Medical Science, Lund UniversityLudwig Institute for Cancer ResearchMidbrain dopamine (mDA) neurons are significantly associated with Parkinson’s disease and yet there is no systematic molecular classification of these heterogenous group of cells. Here authors use single cell RNA sequencing of isolated mouse neurons expressing the transcription factor Pitx3 (broad mDA neuronal marker) to identify and characterize seven neuron subgroups divided in two major branches of developing Pitx3-expressing neurons.https://doi.org/10.1038/s41467-019-08453-1 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Katarína Tiklová Åsa K. Björklund Laura Lahti Alessandro Fiorenzano Sara Nolbrant Linda Gillberg Nikolaos Volakakis Chika Yokota Markus M. Hilscher Thomas Hauling Fredrik Holmström Eliza Joodmardi Mats Nilsson Malin Parmar Thomas Perlmann |
| spellingShingle |
Katarína Tiklová Åsa K. Björklund Laura Lahti Alessandro Fiorenzano Sara Nolbrant Linda Gillberg Nikolaos Volakakis Chika Yokota Markus M. Hilscher Thomas Hauling Fredrik Holmström Eliza Joodmardi Mats Nilsson Malin Parmar Thomas Perlmann Single-cell RNA sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development Nature Communications |
| author_facet |
Katarína Tiklová Åsa K. Björklund Laura Lahti Alessandro Fiorenzano Sara Nolbrant Linda Gillberg Nikolaos Volakakis Chika Yokota Markus M. Hilscher Thomas Hauling Fredrik Holmström Eliza Joodmardi Mats Nilsson Malin Parmar Thomas Perlmann |
| author_sort |
Katarína Tiklová |
| title |
Single-cell RNA sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development |
| title_short |
Single-cell RNA sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development |
| title_full |
Single-cell RNA sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development |
| title_fullStr |
Single-cell RNA sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development |
| title_full_unstemmed |
Single-cell RNA sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development |
| title_sort |
single-cell rna sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2019-02-01 |
| description |
Midbrain dopamine (mDA) neurons are significantly associated with Parkinson’s disease and yet there is no systematic molecular classification of these heterogenous group of cells. Here authors use single cell RNA sequencing of isolated mouse neurons expressing the transcription factor Pitx3 (broad mDA neuronal marker) to identify and characterize seven neuron subgroups divided in two major branches of developing Pitx3-expressing neurons. |
| url |
https://doi.org/10.1038/s41467-019-08453-1 |
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