VHL dependent expression of REDD1 and PDK3 proteins in clear-cell renal cell carcinoma

VHL dependent expression of REDD1 and PDK3 proteins in clear-cell renal cell carcinoma

Background: Sporadic clear-cell renal cell carcinoma (ccRCC) is associated with mutations in the VHL gene, upregulated mammalian target of rapamycin (mTOR) activity and glycolytic metabolism. Here, we analyze the effect of VHL mutational status on the expression level of mTOR, eIF4E-BP1, AMPK, REDD1...

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Bibliographic Details
Main Authors: Ilić Bojana B., Antić Jadranka A., Banković Jovana Z., Milićević Ivana T., Rodić Gordana S., Ilić Dušan S., Tulić Cane D., Todorović Vera N., Damjanović Svetozar S.
Format: Article
Language:English
Published: Society of Medical Biochemists of Serbia, Belgrade 2018-01-01
Series:Journal of Medical Biochemistry
Subjects:
clear-cell renal cell carcinoma
mammalian target of rapamycin
pyruvate dehydrogenase kinase 3
regulated in development and dna damage responses
vhl gene
Online Access:https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2018/1452-82581801031I.pdf

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