Validation of C-Reactive Protein and CURB-65 in The First Hospital Admission Community Acquired Pneumonia Patient as A Predictor 30 Days Mortality

• Main Authors: Borries Foresto Buharman, Ceva Wicaksono Pitoyo, Gurmeet Singh, Sukamto Koesnoe
• Format: Article
• Language: Indonesian
• Published: Department of Internal Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo Hospital 2018-03-01
• Series: Jurnal Penyakit Dalam Indonesia
• Subjects: 30 days mortality; C-Reactive Protein; CURB-65 score; hospitalized community acquired pneumonia patient
• Online Access: http://jurnalpenyakitdalam.ui.ac.id/index.php/jpdi/article/view/165/139

Introduction. CURB-65 is a scoring system to evaluate the degree of pneumonia, but some researches identified that its performance to predict mortality was below expectations. Therefore, we need other prognostic factor as an added value. C-Reactive Protein has a role as an independent factor to predict mortality in community acquired pneumonia. This study aims to evaluate role of C-Reactive Protein in CURB-65 score to predict 30 days mortality in hospitalized community acquired pneumonia patient. Method. A prospective cohort study was conducted to hospitalized community acquired pneumonia patients in Cipto Mangunkusumo Hospital, Jakarta from October to November 2017. Outcome of the study was mortality in 30 days. Performance of CURB-65 score was evaluated before and after addition of C-Reactive Protein. Discrimination was evaluated with area under curved (AUC). Results. Total of 200 patients were included in this study with number of mortality was 37%. Performance discrimination CURB-65 score was shown by ROC curve, the AUC is 70,1% (CI 95% 0,62–0,77). After addition of C-Reactive Protein based of cut off (≥48,5 mg/L), the AUC score improved to 88,0% (CI 95% 0,83–0,92). Conclusion. C-Reactive Protein has a role to CURB-65 score to predict 30 days mortality in hospitalized community acquired pneumonia patient.