Expression of the stem cell marker CD133 is related to tumor development in colorectal carcinogenesis

Expression of the stem cell marker CD133 is related to tumor development in colorectal carcinogenesis

Summary: Background/Objective: CD133 is currently considered the most robust surface marker for colorectal cancer stem cells. Two meta-analysis reports have suggested that CD133 expression is significantly associated with shorter survival, and CD133 may play an important role in the progression of...

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Main Authors: Shinsuke Kazama, Junko Kishikawa, Tomomichi Kiyomatsu, Kazushige Kawai, Hiroaki Nozawa, Soichiro Ishihara, Toshiaki Watanabe
Format: Article
Language:English
Published: Elsevier 2018-05-01
Series:Asian Journal of Surgery
Online Access:http://www.sciencedirect.com/science/article/pii/S1015958416303359
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spelling doaj-fb0ed83d525f49819c65a0c06c0075da2020-11-24T23:26:39ZengElsevierAsian Journal of Surgery1015-95842018-05-01413274278Expression of the stem cell marker CD133 is related to tumor development in colorectal carcinogenesisShinsuke Kazama0Junko Kishikawa1Tomomichi Kiyomatsu2Kazushige Kawai3Hiroaki Nozawa4Soichiro Ishihara5Toshiaki Watanabe6Corresponding author. Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.; Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, JapanDivision of Surgical Oncology, Department of Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, JapanDivision of Surgical Oncology, Department of Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, JapanDivision of Surgical Oncology, Department of Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, JapanDivision of Surgical Oncology, Department of Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, JapanDivision of Surgical Oncology, Department of Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, JapanDivision of Surgical Oncology, Department of Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, JapanSummary: Background/Objective: CD133 is currently considered the most robust surface marker for colorectal cancer stem cells. Two meta-analysis reports have suggested that CD133 expression is significantly associated with shorter survival, and CD133 may play an important role in the progression of colorectal cancer. However, the role of CD133 in colorectal adenoma has not been fully elucidated. Methods: We used immunohistochemistry to evaluate CD133 expression in 200 endoscopically resected colorectal polyps from 200 patients and 20 normal mucosae between January 1993 and December 1996. Results: CD133 staining was positive in 17.9% of the colorectal adenomas. Moreover, CD133 expression was associated with differentiation status (p = 0.003) and tumor size (p = 0.03). Conclusion: CD133 might play an important role in tumor development. Keywords: CD133, colorectal adenoma, immunohistochemistryhttp://www.sciencedirect.com/science/article/pii/S1015958416303359
collection DOAJ
language English
format Article
sources DOAJ
author Shinsuke Kazama
Junko Kishikawa
Tomomichi Kiyomatsu
Kazushige Kawai
Hiroaki Nozawa
Soichiro Ishihara
Toshiaki Watanabe
spellingShingle Shinsuke Kazama
Junko Kishikawa
Tomomichi Kiyomatsu
Kazushige Kawai
Hiroaki Nozawa
Soichiro Ishihara
Toshiaki Watanabe
Expression of the stem cell marker CD133 is related to tumor development in colorectal carcinogenesis
Asian Journal of Surgery
author_facet Shinsuke Kazama
Junko Kishikawa
Tomomichi Kiyomatsu
Kazushige Kawai
Hiroaki Nozawa
Soichiro Ishihara
Toshiaki Watanabe
author_sort Shinsuke Kazama
title Expression of the stem cell marker CD133 is related to tumor development in colorectal carcinogenesis
title_short Expression of the stem cell marker CD133 is related to tumor development in colorectal carcinogenesis
title_full Expression of the stem cell marker CD133 is related to tumor development in colorectal carcinogenesis
title_fullStr Expression of the stem cell marker CD133 is related to tumor development in colorectal carcinogenesis
title_full_unstemmed Expression of the stem cell marker CD133 is related to tumor development in colorectal carcinogenesis
title_sort expression of the stem cell marker cd133 is related to tumor development in colorectal carcinogenesis
publisher Elsevier
series Asian Journal of Surgery
issn 1015-9584
publishDate 2018-05-01
description Summary: Background/Objective: CD133 is currently considered the most robust surface marker for colorectal cancer stem cells. Two meta-analysis reports have suggested that CD133 expression is significantly associated with shorter survival, and CD133 may play an important role in the progression of colorectal cancer. However, the role of CD133 in colorectal adenoma has not been fully elucidated. Methods: We used immunohistochemistry to evaluate CD133 expression in 200 endoscopically resected colorectal polyps from 200 patients and 20 normal mucosae between January 1993 and December 1996. Results: CD133 staining was positive in 17.9% of the colorectal adenomas. Moreover, CD133 expression was associated with differentiation status (p = 0.003) and tumor size (p = 0.03). Conclusion: CD133 might play an important role in tumor development. Keywords: CD133, colorectal adenoma, immunohistochemistry
url http://www.sciencedirect.com/science/article/pii/S1015958416303359
work_keys_str_mv AT shinsukekazama expressionofthestemcellmarkercd133isrelatedtotumordevelopmentincolorectalcarcinogenesis
AT junkokishikawa expressionofthestemcellmarkercd133isrelatedtotumordevelopmentincolorectalcarcinogenesis
AT tomomichikiyomatsu expressionofthestemcellmarkercd133isrelatedtotumordevelopmentincolorectalcarcinogenesis
AT kazushigekawai expressionofthestemcellmarkercd133isrelatedtotumordevelopmentincolorectalcarcinogenesis
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