Age-Dependent Relationship Between Plasma Aβ40 and Aβ42 and Total Tau Levels in Cognitively Normal Subjects

Age-Dependent Relationship Between Plasma Aβ40 and Aβ42 and Total Tau Levels in Cognitively Normal Subjects

Both amyloid plaques and neurofibrillary tangles are pathological hallmarks in the brains of patients with Alzheimer’s disease (AD). However, the constituents of these hallmarks, amyloid beta (Aβ) 40, Aβ42, and total Tau (t-Tau), have been detected in the blood of cognitively normal subjects by usin...

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Main Authors: Lih-Fen Lue, Ming-Chyi Pai, Ta-Fu Chen, Chaur-Jong Hu, Li-Kai Huang, Wei-Che Lin, Chau-Chung Wu, Jian-Shing Jeng, Kaj Blennow, Marwan N. Sabbagh, Sui-Hing Yan, Pei-Ning Wang, Shieh-Yueh Yang, Hiroyuki Hatsuta, Satoru Morimoto, Akitoshi Takeda, Yoshiaki Itoh, Jun Liu, Haiqun Xie, Ming-Jang Chiu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer
plasma
amyloid
tau
immunomagnetic reduction
cognitively normal subjects
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2019.00222/full

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