A Ras-like domain in the light intermediate chain bridges the dynein motor to a cargo-binding region

A Ras-like domain in the light intermediate chain bridges the dynein motor to a cargo-binding region

Cytoplasmic dynein, a microtubule-based motor protein, transports many intracellular cargos by means of its light intermediate chain (LIC). In this study, we have determined the crystal structure of the conserved LIC domain, which binds the motor heavy chain, from a thermophilic fungus. We show that...

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Bibliographic Details
Main Authors: Courtney M Schroeder, Jonathan ML Ostrem, Nicholas T Hertz, Ronald D Vale
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-10-01
Series:eLife
Subjects:
molecular motor
G protein
intracellular motility
Rab effector
dynein subunit
Online Access:https://elifesciences.org/articles/03351

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