Integrin α7 and Extracellular Matrix Laminin 211 Interaction Promotes Proliferation of Acute Myeloid Leukemia Cells and Is Associated with Granulocytic Sarcoma

Integrin α7 and Extracellular Matrix Laminin 211 Interaction Promotes Proliferation of Acute Myeloid Leukemia Cells and Is Associated with Granulocytic Sarcoma

Acute myeloid leukemia (AML) with granulocytic sarcoma (GS) is characterized by poor prognosis; however, its underlying mechanism is unclear. Bone marrow samples from 64 AML patients (9 with GS and 55 without GS) together with AML cell lines PL21, THP1, HL60, Kasumi-1, and KG-1 were used to elucidat...

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Bibliographic Details
Main Authors: Nobuhiko Kobayashi, Tsukasa Oda, Makiko Takizawa, Takuma Ishizaki, Norifumi Tsukamoto, Akihiko Yokohama, Hisashi Takei, Takayuki Saitoh, Hiroaki Shimizu, Kazuki Honma, Kei Kimura-Masuda, Yuko Kuroda, Rei Ishihara, Yuki Murakami, Hirokazu Murakami, Hiroshi Handa
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Cancers
Subjects:
acute myelogenous leukemia
granulocytic sarcoma
integrin
laminin
extracellular matrix
Online Access:https://www.mdpi.com/2072-6694/12/2/363

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