Smart Hydrogels: Preparation, Characterization, and Determination of Transition Points of Crosslinked <i>N</i>-Isopropyl Acrylamide/Acrylamide/Carboxylic Acids Polymers

• Main Authors: Yasemin Işıkver, Dursun Saraydın
• Format: Article
• Language: English
• Published: MDPI AG 2021-08-01
• Series: Gels
• Subjects: smart hydrogel; NIPAAm; LCST; transition point; sigmoidal equation; human serum albumin
• Online Access: https://www.mdpi.com/2310-2861/7/3/113

Smart hydrogels (SH) were prepared by thermal free radical polymerization of <i>N</i>-isopropyl acrylamide (NIPAAm), acrylamide (AAm) with acrylic acid (A) or maleic acid (M), and <i>N</i>,<i>N</i>′-methylene bisacrylamide. Spectroscopic and thermal characterizations of SHs were performed using FTIR, TGA, and DSC. To determine the effects of SHs on swelling characteristics, swelling studies were performed in different solvents, solutions, temperatures, pHs, and ionic strengths. In addition, cycle equilibrium swelling studies were carried out at different temperatures and pHs. The temperature and pH transition points of SHs are calculated using a sigmoidal equation. The pH transition points were calculated as 5.2 and 4.2 for SH-M and SH-A, respectively. The NIPAAm/AAm hydrogel exhibits a critical solution temperature (LCST) of 28.35 °C, while the SH-A and SH-M hydrogels exhibit the LCST of 34.215 °C and 28.798 °C, respectively, and the LCST of SH-A is close to the body. temperature. Commercial (CHSA) and blood human serum albumin (BHSA) were used to find the adsorption properties of biopolymers on SHs. SH-M was the most efficient SH, adsorbing 49% of CHSA while absorbing 16% of BHSA. In conclusion, the sigmoidal equation or Gaussian approach can be a useful tool for chemists, chemical engineers, polymer and plastics scientists to find the transition points of smart hydrogels.