Combined Stimulation with the Tumor Necrosis Factor α and the Epidermal Growth Factor Promotes the Proliferation of Hepatocytes in Rat Liver Cultured Slices

Combined Stimulation with the Tumor Necrosis Factor α and the Epidermal Growth Factor Promotes the Proliferation of Hepatocytes in Rat Liver Cultured Slices

The culture liver slices are mainly used to investigate drug metabolism and xenobiotic-mediated liver injuries while apoptosis and proliferation remain unexplored in this culture model. Here, we show a transient increase in LDH release and caspase activities indicating an ischemic injury during the...

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Bibliographic Details
Main Authors: Francis Finot, Régis Masson, Fabienne Desmots, Catherine Ribault, Nicole Bichet, Joan A. Vericat, Patricia Lafouge, Christiane Guguen-Guillouzo, Pascal Loyer
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:International Journal of Hepatology
Online Access:http://dx.doi.org/10.1155/2012/785786

Internet

http://dx.doi.org/10.1155/2012/785786

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