Synthesis, Spectral Characterization and Evaluation of Pharmacodynamic Activity of Copper and Nickel Complexes of Ethambutol Dihydrochloride

Synthesis, Spectral Characterization and Evaluation of Pharmacodynamic Activity of Copper and Nickel Complexes of Ethambutol Dihydrochloride

Nickel and copper complexes of ethambutol [EB] were synthesized and characterized. On the basis of spectral and thermal data an octahedral geometry was assigned to the complexes with molecular formulae [Cu(C10 H24 N2 O2)2Cl2] 5H2O and [Ni(C10 H24 N2 O2)2Cl2] 2H2O. Coordination of ethylene diamine de...

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Main Authors: M. Mathrusri Annapurna, M. E. Bhanoji Rao, B. V. V. Ravi Kumar
Format: Article
Language:English
Published: Hindawi Limited 2006-01-01
Series:E-Journal of Chemistry
Online Access:http://dx.doi.org/10.1155/2006/476513
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spelling doaj-faec86337bbc4858b8aff6cf44457dda2020-11-25T02:46:56ZengHindawi LimitedE-Journal of Chemistry0973-49452090-98102006-01-013427427710.1155/2006/476513Synthesis, Spectral Characterization and Evaluation of Pharmacodynamic Activity of Copper and Nickel Complexes of Ethambutol DihydrochlorideM. Mathrusri Annapurna0M. E. Bhanoji Rao1B. V. V. Ravi Kumar2Department of Pharmaceutical Chemistry, Roland Institute of Pharmaceutical Sciences, Ambapua, Berhampur, Orissa-760010, IndiaDepartment of Pharmaceutical Chemistry, Roland Institute of Pharmaceutical Sciences, Ambapua, Berhampur, Orissa-760010, IndiaDepartment of Pharmaceutical Chemistry, Roland Institute of Pharmaceutical Sciences, Ambapua, Berhampur, Orissa-760010, IndiaNickel and copper complexes of ethambutol [EB] were synthesized and characterized. On the basis of spectral and thermal data an octahedral geometry was assigned to the complexes with molecular formulae [Cu(C10 H24 N2 O2)2Cl2] 5H2O and [Ni(C10 H24 N2 O2)2Cl2] 2H2O. Coordination of ethylene diamine derivative to the metal ion was proposed. The anti-tubercular activity of the complexes was evaluated using Lowenstein–Jensen medium and MABA [Microplate Alamar Blue Assay] methods.http://dx.doi.org/10.1155/2006/476513
collection DOAJ
language English
format Article
sources DOAJ
author M. Mathrusri Annapurna
M. E. Bhanoji Rao
B. V. V. Ravi Kumar
spellingShingle M. Mathrusri Annapurna
M. E. Bhanoji Rao
B. V. V. Ravi Kumar
Synthesis, Spectral Characterization and Evaluation of Pharmacodynamic Activity of Copper and Nickel Complexes of Ethambutol Dihydrochloride
E-Journal of Chemistry
author_facet M. Mathrusri Annapurna
M. E. Bhanoji Rao
B. V. V. Ravi Kumar
author_sort M. Mathrusri Annapurna
title Synthesis, Spectral Characterization and Evaluation of Pharmacodynamic Activity of Copper and Nickel Complexes of Ethambutol Dihydrochloride
title_short Synthesis, Spectral Characterization and Evaluation of Pharmacodynamic Activity of Copper and Nickel Complexes of Ethambutol Dihydrochloride
title_full Synthesis, Spectral Characterization and Evaluation of Pharmacodynamic Activity of Copper and Nickel Complexes of Ethambutol Dihydrochloride
title_fullStr Synthesis, Spectral Characterization and Evaluation of Pharmacodynamic Activity of Copper and Nickel Complexes of Ethambutol Dihydrochloride
title_full_unstemmed Synthesis, Spectral Characterization and Evaluation of Pharmacodynamic Activity of Copper and Nickel Complexes of Ethambutol Dihydrochloride
title_sort synthesis, spectral characterization and evaluation of pharmacodynamic activity of copper and nickel complexes of ethambutol dihydrochloride
publisher Hindawi Limited
series E-Journal of Chemistry
issn 0973-4945
2090-9810
publishDate 2006-01-01
description Nickel and copper complexes of ethambutol [EB] were synthesized and characterized. On the basis of spectral and thermal data an octahedral geometry was assigned to the complexes with molecular formulae [Cu(C10 H24 N2 O2)2Cl2] 5H2O and [Ni(C10 H24 N2 O2)2Cl2] 2H2O. Coordination of ethylene diamine derivative to the metal ion was proposed. The anti-tubercular activity of the complexes was evaluated using Lowenstein–Jensen medium and MABA [Microplate Alamar Blue Assay] methods.
url http://dx.doi.org/10.1155/2006/476513
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AT bvvravikumar synthesisspectralcharacterizationandevaluationofpharmacodynamicactivityofcopperandnickelcomplexesofethambutoldihydrochloride
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