Prdm12 Directs Nociceptive Sensory Neuron Development by Regulating the Expression of the NGF Receptor TrkA

Prdm12 Directs Nociceptive Sensory Neuron Development by Regulating the Expression of the NGF Receptor TrkA

Summary: In humans, many cases of congenital insensitivity to pain (CIP) are caused by mutations of components of the NGF/TrkA signaling pathway, which is required for survival and specification of nociceptors and plays a major role in pain processing. Mutations in PRDM12 have been identified in CIP...

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Main Authors: Simon Desiderio, Simon Vermeiren, Claude Van Campenhout, Sadia Kricha, Elisa Malki, Sven Richts, Emily V. Fletcher, Thomas Vanwelden, Bela Z. Schmidt, Kristine A. Henningfeld, Tomas Pieler, C. Geoffrey Woods, Vanja Nagy, Catherine Verfaillie, Eric J. Bellefroid
Format: Article
Language:English
Published: Elsevier 2019-03-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719302839

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