The Implication of STEP in Synaptic Plasticity and Cognitive Impairments in Alzheimer’s Disease and Other Neurological Disorders

The Implication of STEP in Synaptic Plasticity and Cognitive Impairments in Alzheimer’s Disease and Other Neurological Disorders

STriatal-Enriched protein tyrosine Phosphatase (STEP) is a tyrosine phosphatase that has been implicated in Alzheimer’s disease (AD), the most common form of dementia, and many other neurological diseases. The protein level and activity of STEP have been found to be elevated in most of these disorde...

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Bibliographic Details
Main Authors: Yacoubou Abdoul Razak Mahaman, Fang Huang, Kidane Siele Embaye, Xiaochuan Wang, Feiqi Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
STEP
GluN2B
GluA2
Fyn
ERK1/2
synapses loss
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.680118/full

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