The Effects of the Melatonin Treatment on the Oxidative Stress and Apoptosis in Diabetic Eye and Brain

The Effects of the Melatonin Treatment on the Oxidative Stress and Apoptosis in Diabetic Eye and Brain

Oxidative stress plays an important role in the development of complications in diabetes mellitus. Antioxidant therapy has been thought to decrease oxidative stress. The objective of the present study was to explore the effects of melatonin (MLT) on oxidative stress in diabetic rat eye and brain ti...

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Main Authors: Tuğba Gürpınar, Nuran Ekerbiçer, Nazan Uysal, Turgay Barut, Figen Tarakçı, M. Ibrahim Tuglu
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:The Scientific World Journal
Online Access:http://dx.doi.org/10.1100/2012/498489
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spelling doaj-fae1cfce4cdf484ca4baa8288268eb592020-11-25T01:13:59ZengHindawi LimitedThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/498489498489The Effects of the Melatonin Treatment on the Oxidative Stress and Apoptosis in Diabetic Eye and BrainTuğba Gürpınar0Nuran Ekerbiçer1Nazan Uysal2Turgay Barut3Figen Tarakçı4M. Ibrahim Tuglu5Department of Pharmacology, Faculty of Medicine, Celal Bayar University, 45030 Manisa, TurkeyDepartment of Physiology, Faculty of Medicine, Celal Bayar University, 45030 Manisa, TurkeyDepartment of Physiology, Faculty of Medicine, Dokuz Eylul University, 35340 Izmir, TurkeyDepartment of Histology and Embriology, Faculty of Medicine, Celal Bayar University, 45030 Manisa, TurkeyDepartment of Vocational School of Health Services, Celal Bayar University, 45030 Manisa, TurkeyDepartment of Histology, Faculty of Medicine, Celal Bayar University, 45030 Manisa, TurkeyOxidative stress plays an important role in the development of complications in diabetes mellitus. Antioxidant therapy has been thought to decrease oxidative stress. The objective of the present study was to explore the effects of melatonin (MLT) on oxidative stress in diabetic rat eye and brain tissue by using immunohistochemical methods. Diabetes was induced by streptozotocin, (STZ, 55 mg/kg/i.p) in adult rats. MLT was given 10 mg/kg/i.p once a day for 2 weeks beginning from the sixth week. Six weeks later, rats were divided into three groups: control (CR), STZ-induced diabetic (STZ), and STZ-induced diabetic group received melatonin (STZ+MLT). Although no significant difference was observed with respect to antioxidant status, NOS activity tended to be higher in the untreated diabetic rats than in the treated rats. It was observed that MLT treatment improved the histopathological changes including apoptosis and oxidative stress in brain and eye in diabetic rat.http://dx.doi.org/10.1100/2012/498489
collection DOAJ
language English
format Article
sources DOAJ
author Tuğba Gürpınar
Nuran Ekerbiçer
Nazan Uysal
Turgay Barut
Figen Tarakçı
M. Ibrahim Tuglu
spellingShingle Tuğba Gürpınar
Nuran Ekerbiçer
Nazan Uysal
Turgay Barut
Figen Tarakçı
M. Ibrahim Tuglu
The Effects of the Melatonin Treatment on the Oxidative Stress and Apoptosis in Diabetic Eye and Brain
The Scientific World Journal
author_facet Tuğba Gürpınar
Nuran Ekerbiçer
Nazan Uysal
Turgay Barut
Figen Tarakçı
M. Ibrahim Tuglu
author_sort Tuğba Gürpınar
title The Effects of the Melatonin Treatment on the Oxidative Stress and Apoptosis in Diabetic Eye and Brain
title_short The Effects of the Melatonin Treatment on the Oxidative Stress and Apoptosis in Diabetic Eye and Brain
title_full The Effects of the Melatonin Treatment on the Oxidative Stress and Apoptosis in Diabetic Eye and Brain
title_fullStr The Effects of the Melatonin Treatment on the Oxidative Stress and Apoptosis in Diabetic Eye and Brain
title_full_unstemmed The Effects of the Melatonin Treatment on the Oxidative Stress and Apoptosis in Diabetic Eye and Brain
title_sort effects of the melatonin treatment on the oxidative stress and apoptosis in diabetic eye and brain
publisher Hindawi Limited
series The Scientific World Journal
issn 1537-744X
publishDate 2012-01-01
description Oxidative stress plays an important role in the development of complications in diabetes mellitus. Antioxidant therapy has been thought to decrease oxidative stress. The objective of the present study was to explore the effects of melatonin (MLT) on oxidative stress in diabetic rat eye and brain tissue by using immunohistochemical methods. Diabetes was induced by streptozotocin, (STZ, 55 mg/kg/i.p) in adult rats. MLT was given 10 mg/kg/i.p once a day for 2 weeks beginning from the sixth week. Six weeks later, rats were divided into three groups: control (CR), STZ-induced diabetic (STZ), and STZ-induced diabetic group received melatonin (STZ+MLT). Although no significant difference was observed with respect to antioxidant status, NOS activity tended to be higher in the untreated diabetic rats than in the treated rats. It was observed that MLT treatment improved the histopathological changes including apoptosis and oxidative stress in brain and eye in diabetic rat.
url http://dx.doi.org/10.1100/2012/498489
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